Mouse Pleckstrin homology domain-containing family A member 4 (PLEKHA4) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PLEKHA4
proveedor
Abbexareference
abx539034Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Pleckstrin homology domain-containing family A member 4 (PLEKHA4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Pleckstrin homology domain-containing family A member 4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PLEKHA4 is a pleckstrin homology (PH) domain-containing protein that binds phosphoinositides, primarily PI(4,5)P2, to localize at plasma and endosomal membranes where it regulates intracellular signaling and membrane trafficking. It plays an important role in the Wnt/β-catenin signaling pathway by interacting with components like Dishevelled proteins, influencing cellular processes such as proliferation, differentiation, and development. PLEKHA4 is expressed in epithelial and immune tissues, where it is involved in actin cytoskeleton remodeling, cell polarity, and vesicular dynamics. Dysregulation of PLEKHA4 has been linked to cancer progression, particularly melanoma, where it enhances Wnt signaling and promotes tumor cell proliferation and migration. Knockdown studies show disrupted Wnt signaling, impaired membrane localization, and defects in actin organization, highlighting its role in phosphoinositide-mediated signaling and cytoskeletal regulation during development and tumorigenesis.
Características del producto
category
ELISA Kits
immunogen target
Pleckstrin homology domain-containing family A member 4 (PLEKHA4)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
PEPP1,PH domain-containing family A member 4,Phosphoinositol 3-phosphate-binding protein 1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PLEKHA4
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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