Family main features
Fc receptor-like (FCRL) proteins are part of the immunoglobulin superfamily (IgSF) and are homologous to classical Fc receptors (FcRs), which are molecules that bind the Fc region of antibodies and mediate immune responses. FCRL proteins are expressed primarily on B cells, where they influence various aspects of B cell activity, development, and differentiation, making them integral to immune regulation and immune tolerance. These receptors do not directly bind antibodies as Fc receptors do but rather have structural similarities to Fc receptors and play diverse roles in modulating immune cell function.
The FCRL family encompasses multiple members (FCRL1 through FCRL6), with each receptor having unique and sometimes overlapping roles. Members of the FCRL family are thought to act as co-receptors, influencing cell signaling and immune responses through their interactions with other immune receptors and ligands. FCRL proteins are particularly notable for their expression on mature and memory B cells, implicating them in adaptive immunity. Dysregulation of FCRL proteins is associated with several autoimmune diseases, lymphomas, and immune deficiencies, highlighting their clinical significance.
FCRL proteins exhibit a complex structure that allows them to interact with different signaling molecules and ligands, which is key to their role in immune modulation:
Immunoglobulin-like (Ig) Domains:
Transmembrane and Cytoplasmic Regions:
Glycosylation Sites:
The FCRL family includes six main members (FCRL1 through FCRL6), each with structural and functional variations:
These receptors are classified based on their expression patterns, structural motifs, and specific functions in immune regulation.
Regulation of B Cell Signaling:
Immune Tolerance and Self-reactivity Control:
Role in Adaptive and Innate Immunity:
Influence on Antibody Responses:
Autoimmune Diseases:
Lymphomas and B cell Malignancies:
Potential as Therapeutic Targets:
The Fc receptor-like (FCRL) family of proteins comprises six major members (FCRL1–6), each with distinct structural and functional properties. Structurally, FCRL proteins contain multiple immunoglobulin-like domains, transmembrane regions, and cytoplasmic signaling motifs (ITIMs and/or ITAMs) that enable them to interact with signaling molecules and modulate immune responses. Unlike classical Fc receptors, FCRL proteins do not bind antibodies directly but influence immune cell activity through modulation of B cell receptor (BCR) signaling and by acting as co-receptors in both adaptive and innate immune pathways.
FCRL proteins are especially relevant in regulating B cell responses, immune tolerance, and antibody production. They play essential roles in balancing immune activation and inhibition, particularly in tissues constantly exposed to antigens, such as mucosal areas. Dysregulation of FCRL proteins has been implicated in autoimmune diseases, lymphomas, and B cell malignancies, highlighting their clinical importance. Genetic variants in FCRL genes have been linked to autoimmune disease susceptibility, while overexpression of certain FCRL proteins is associated with lymphomas.
Given their significance in immune regulation, FCRL proteins are emerging as promising therapeutic targets. Modulating FCRL activity holds potential for the treatment of autoimmune diseases, where enhanced immune tolerance is desired, as well as for cancers, where controlled immune activation can help eliminate malignant cells. In summary, FCRL proteins represent a unique family of immunoregulatory receptors with implications across a range of immune-related diseases, underscoring their value in both fundamental immunology and clinical therapeutics.
Fc receptor like 1 (FCRL1)
Fc receptor-like protein 1FcR-like protein 1,FcRL1,Fc receptor homolog 1,FCRH1,IFGP1,IRTA5,CD307a
Fc receptor like 2 (FCRL2)
" Fc receptor-like protein 2,FCRH2,IFGP4,IRTA4,SPAP1,CD307b,SPAP1A,SPAP1B,SPAP1C,FcR-like protein 2,FcRL2,IFGP family protein 4"
Fc receptor like 3 (FCRL3)
Fc receptor-like protein 3,MAIA,FCRH3,IFGP3,IRTA3,SPAP2,CD307c,Fc receptor homolog 3,IFGP family protein 3,Hifgp3
Fc receptor like 4 (FCRL4)
Fc receptor-like protein 4,FCRH4,IGFP2,IRTA1,CD307d,FcR-like protein 4,FcRL4,IFGP family protein 2,hIFGP2
Fc receptor like 5 (FCRL5)
Fc receptor-like protein 5,CD307,FCRH5,IRTA2,BXMAS1,CD307e,PRO820,FcR-like protein 5,FcRL5,Fc receptor homolog 5
Fc receptor like 6 (FCRL6)
Fc receptor-like protein 6,FcRH6,FcR-like protein 6,FcRL6,Fc receptor homolog 6,IFGP6
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con FCRL - Fc receptor like
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 51 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | FCRL1 | abx523752 | Human Fc receptor-like protein 1 (FCRL1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q96LA6 | RUO | ||
Abbexa | FCRL3 | abx352196 | Human Fc Receptor-Like 3 (FCRL3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 587.5 | 96 tests | Q96P31 | RUO |
Abbexa | FCRL4 | abx523756 | Human Fc receptor-like protein 4 (FCRL4) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q96PJ5 | RUO | ||
Abbexa | FCRL5 | abx523757 | Human Fc receptor-like protein 5 (FCRL5) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | < 0.43 ng/ml | 687.5 | 96 tests | Q96RD9 | RUO |
Abbexa | FCRL6 | abx523759 | Human Fc Receptor-Like Protein 6 (FCRL6) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.625 ng/ml - 40 ng/ml | < 0.3 ng/ml | 687.5 | 96 tests | Q6DN72 | RUO |
Abbexa | FCRL1 | abx523753 | Mouse Fc receptor-like protein 1 (FCRL1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8R4Y0 | RUO | ||
Abbexa | FCRL5 | abx523758 | Mouse Fc receptor-like protein 5 (FCRL5) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | Q68SN8 | RUO |
Abbexa | FCRL6 | abx523760 | Mouse Fc Receptor-Like Protein 6 (FCRL6) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.14 ng/ml | 687.5 | 96 tests | A1YIY0 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | FCRL1 | abx432684 | Fc Receptor-Like Protein 1 (FCRL1) Antibody | Human | Polyclonal | Goat | Fc Receptor-Like Protein 1 (FCRL1) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | FCRL1 | abx030308 | Fc Receptor-Like Protein 1 (FCRL1) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 1 (FCRL1) | Unconjugated | ELISA, WB | 250 | 80 µl | Q96LA6 | RUO | |
Abbexa | FCRL1 | abx432683 | Fc Receptor-Like Protein 1 (FCRL1) Antibody | Human | Polyclonal | Goat | Fc Receptor-Like Protein 1 (FCRL1) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | FCRL1 | abx347172 | Fc receptor-like protein 1 (FCRL1) Antibody | Human | Monoclonal | Mouse | Fc receptor-like protein 1 (FCRL1) | Unconjugated | FCM | 287.5 | 0.1 mg | Q96LA6 | RUO | |
Abbexa | FCRL1 | abx376006 | Fc Receptor-Like Protein 1 (FCRL1) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 1 (FCRL1) | Unconjugated | ELISA, WB | 337.5 | 100 µg | Q96LA6 | RUO | |
Abbexa | FCRL2 | abx432685 | Fc Receptor-Like Protein 2 (FCRL2) Antibody | Human | Polyclonal | Goat | Fc Receptor-Like Protein 2 (FCRL2) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | FCRL2 | abx321221 | Fc Receptor-Like Protein 2 (FCRL2) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 2 (FCRL2) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q96LA5 | RUO | |
Abbexa | FCRL2 | abx376081 | Fc Receptor-Like Protein 2 (FCRL2) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 2 (FCRL2) | Unconjugated | ELISA, WB | 337.5 | 100 µg | Q96LA5 | RUO | |
Abbexa | FCRL2 | abx347159 | Fc Receptor-Like Protein 2 (FCRL2) Antibody | Human | Monoclonal | Mouse | Fc Receptor-Like Protein 2 (FCRL2) | FCM | 287.5 | 0.1 mg | Q96LA5 | RUO | ||
Abbexa | FCRL2 | abx322029 | Fc Receptor-Like Protein 2 (FCRL2) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 2 (FCRL2) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q96LA5 | RUO | |
Abbexa | FCRL2 | abx125841 | Fc Receptor-Like Protein 2 (FCRL2) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 2 (FCRL2) | Unconjugated | WB | 175 | 20 µl | Q96LA5 | RUO | |
Abbexa | FCRL3 | abx031326 | Fc Receptor-Like 3 (FCRL3) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like 3 (FCRL3) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q96P31 | RUO | |
Abbexa | FCRL3 | abx348572 | Fc receptor-like protein 3 (FCRL3) Antibody (HRP) | Human | Polyclonal | Rabbit | Fc receptor-like protein 3 (FCRL3) | HRP | ELISA | 162.5 | 20 µg | Q96P31 | RUO | |
Abbexa | FCRL3 | abx348573 | Fc receptor-like protein 3 (FCRL3) Antibody (FITC) | Human | Polyclonal | Rabbit | Fc receptor-like protein 3 (FCRL3) | FITC | 162.5 | 20 µg | Q96P31 | RUO | ||
Abbexa | FCRL3 | abx348571 | Fc receptor-like protein 3 (FCRL3) Antibody | Human | Polyclonal | Rabbit | Fc receptor-like protein 3 (FCRL3) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q96P31 | RUO | |
Abbexa | FCRL3 | abx348574 | Fc receptor-like protein 3 (FCRL3) Antibody (Biotin) | Human | Polyclonal | Rabbit | Fc receptor-like protein 3 (FCRL3) | Biotin | ELISA | 162.5 | 20 µg | Q96P31 | RUO | |
Abbexa | FCRL3 | abx347158 | Fc Receptor-Like Protein 3 (FCRL3) Antibody | Human | Monoclonal | Mouse | Fc Receptor-Like Protein 3 (FCRL3) | FCM | 287.5 | 0.1 mg | Q96P31 | RUO | ||
Abbexa | FCRL3 | abx125843 | Fc Receptor-Like 3 (FCRL3) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like 3 (FCRL3) | Unconjugated | WB | 175 | 20 µl | Q96P31 | RUO | |
Abbexa | FCRL3 | abx125842 | Fc Receptor-Like 3 (FCRL3) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like 3 (FCRL3) | Unconjugated | WB | 175 | 20 µl | Q96P31 | RUO | |
Abbexa | FCRL4 | abx309173 | Fc Receptor-Like Protein 4 (FCRL4) Antibody (HRP) | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 4 (FCRL4) | HRP | ELISA | 162.5 | 20 µg | Q96PJ5 | RUO | |
Abbexa | FCRL4 | abx309175 | Fc Receptor-Like Protein 4 (FCRL4) Antibody (Biotin) | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 4 (FCRL4) | Biotin | ELISA | 162.5 | 20 µg | Q96PJ5 | RUO | |
Abbexa | FCRL4 | abx309174 | Fc Receptor-Like Protein 4 (FCRL4) Antibody (FITC) | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 4 (FCRL4) | FITC | 162.5 | 20 µg | Q96PJ5 | RUO | ||
Abbexa | FCRL4 | abx318313 | Fc Receptor-Like Protein 4 (FCRL4) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 4 (FCRL4) | Unconjugated | ELISA, WB | 162.5 | 20 µg | Q96PJ5 | RUO | |
Abbexa | FCRL4 | abx347171 | Fc Receptor-Like Protein 4 (FCRL4) Antibody | Human | Monoclonal | Mouse | Fc Receptor-Like Protein 4 (FCRL4) | Unconjugated | FCM | 287.5 | 0.1 mg | Q96PJ5 | RUO | |
Abbexa | FCRL4 | abx347175 | Fc Receptor-Like Protein 4 (FCRL4) Antibody (PE) | Human | Monoclonal | Mouse | Fc Receptor-Like Protein 4 (FCRL4) | PE | FCM | 400 | 100 tests | Q96PJ5 | RUO | |
Abbexa | FCRL4 | abx037262 | Fc Receptor-Like Protein 4 (FCRL4) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 4 (FCRL4) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | FCRL4 | abx125844 | Fc Receptor-Like Protein 4 (FCRL4) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 4 (FCRL4) | Unconjugated | WB | 175 | 20 µl | Q96PJ5 | RUO | |
Abbexa | FCRL5 | abx015192 | Fc Receptor-Like Protein 5 (FCRL5) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 5 (FCRL5) | Unconjugated | ELISA, WB | 43.75 | 10 µg | Q96RD9 | RUO | |
Abbexa | FCRL5 | abx348578 | Fc receptor-like protein 5 (FCRL5) Antibody (Biotin) | Human | Polyclonal | Rabbit | Fc receptor-like protein 5 (FCRL5) | Biotin | ELISA | 250 | 50 µl | Q96RD9 | RUO | |
Abbexa | FCRL5 | abx348577 | Fc receptor-like protein 5 (FCRL5) Antibody (FITC) | Human | Polyclonal | Rabbit | Fc receptor-like protein 5 (FCRL5) | FITC | 250 | 50 µl | Q96RD9 | RUO | ||
Abbexa | FCRL5 | abx348576 | Fc receptor-like protein 5 (FCRL5) Antibody (HRP) | Human | Polyclonal | Rabbit | Fc receptor-like protein 5 (FCRL5) | HRP | ELISA | 250 | 50 µl | Q96RD9 | RUO | |
Abbexa | FCRL5 | abx037099 | Fc Receptor-Like Protein 5 (FCRL5) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 5 (FCRL5) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | FCRL5 | abx323355 | Fc Receptor Like 5 (FCRL5) Antibody | Human | Polyclonal | Rabbit | Fc Receptor Like 5 (FCRL5) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q96RD9 | RUO | |
Abbexa | FCRL5 | abx348575 | Fc receptor-like protein 5 (FCRL5) Antibody | Human | Polyclonal | Rabbit | Fc receptor-like protein 5 (FCRL5) | Unconjugated | ELISA, IF/ICC | 250 | 50 µl | Q96RD9 | RUO | |
Abbexa | FCRL5 | abx028752 | Fc Receptor-Like Protein 5 (FCRL5) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 5 (FCRL5) | Unconjugated | ELISA, WB | 250 | 80 µl | Q96RD9 | RUO | |
Abbexa | FCRL5 | abx323655 | Fc Receptor Like 5 (FCRL5) Antibody | Human | Polyclonal | Rabbit | Fc Receptor Like 5 (FCRL5) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q96RD9 | RUO | |
Abbexa | FCRL6 | abx307565 | Fc Receptor-Like Protein 6 (FCRL6) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 6 (FCRL6) | Unconjugated | ELISA | 162.5 | 20 µg | Q6DN72 | RUO | |
Abbexa | FCRL6 | abx322047 | Fc Receptor-Like Protein 6 (FCRL6) Antibody | Human | Polyclonal | Rabbit | Fc Receptor-Like Protein 6 (FCRL6) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q6DN72 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | FCRL1 | abx692498 | Mouse Fc Receptor-Like Protein 1 (FCRL1) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | Q8R4Y0-2 | RUO | |
Abbexa | FCRL1 | abx690609 | Mouse Fc Receptor-Like Protein 1 (FCRL1) Protein | Mouse | Recombinant | Human | SDS-PAGE | 225 | 10 µg | Q8R4Y0 | RUO | |
Abbexa | FCRL1 | abx690649 | Human Fc Receptor-Like Protein 1 (FCRL1) Protein | Human | Recombinant | Human | SDS-PAGE | 200 | 10 µg | Q96LA6 | RUO | |
Abbexa | FCRL1 | abx692115 | Human Fc Receptor-Like Protein 1 (FCRL1) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 487.5 | 50 µg | RUO | ||
FineTest | FCRL6 | P6015 | Recombinant Human FCRL6 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q6DN72 | RUO |
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