Fc Receptor-Like Protein 4 (FCRL4) Antibody

Este producto es parte de FCRL - Fc receptor like
Product Graph
312€ (0.1 mg)

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935106861
info@markelab.com
name
Fc Receptor-Like Protein 4 (FCRL4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx347171
tested applications
FCM

Description

Fc Receptor-Like Protein 4 (FCRL4) Antibody is a mouse monoclonal antibody against Fc Receptor-Like Protein 4 (FCRL4).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Fc Receptor-Like Protein 4 (FCRL4)
Host
Mouse
Reactivity
Human
Recommended Dilution
FCM: 2-5 μg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG2a Kappa
Clone ID
P633
Size 1
0.1 mg
Tested Applications
FCM
Buffer
PBS solution with 15 mM sodium azide.
Availability
Shipped within 5-12 working days.
Storage
Store at 2-8°C. Do not freeze.
Dry Ice
No
UniProt ID
Q96PJ5
Gene ID
83417
OMIM
605876
Alias
Fc receptor-like protein 4,FCRH4,IGFP2,IRTA1,CD307d,FcR-like protein 4,FcRL4,IFGP family protein 2,hIFGP2
Background
Antibody anti-FCRL4
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

Fc Receptor Like 4 (FCRL4) is a transmembrane protein expressed on a subset of memory B cells, predominantly in mucosal and inflamed tissues. Unlike other Fc receptor-like proteins, FCRL4 has a distinct role in dampening B cell receptor (BCR) signaling. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail, allowing it to inhibit activation signals and antibody production. FCRL4 expression is often upregulated in chronic infections and autoimmune diseases, where it is associated with an exhausted B cell phenotype, potentially contributing to immune dysregulation and impaired humoral responses.
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