Fc Receptor-Like 3 (FCRL3) Antibody

Name: Fc Receptor-Like 3 (FCRL3) Antibody
Brand: Abbexa
SKU: abx031326
Price: 292.5 EUR
Availability: OnlineOnly

Este producto es parte de FCRL - Fc receptor like

Pida mas información

935106861

info@markelab.com

Precio

292.5€ (80 µl)

Antibody anti-FCRL3

proveedor

Abbexa

reference

abx031326

Tested Applications

ELISA, WB

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.

Background

Fc Receptor Like 3 (FCRL3) is expressed on B cells, regulatory T cells, and some natural killer cells, functioning as an immune checkpoint molecule. The presence of ITIMs in its structure supports its inhibitory role in immune regulation, particularly in dampening autoimmunity. FCRL3 polymorphisms have been linked to autoimmune diseases such as rheumatoid arthritis and type 1 diabetes, where genetic variants contribute to increased susceptibility. Collectively, the FCRL family represents a critical set of regulators for immune cell function, offering potential therapeutic targets for autoimmune disorders and B cell-related malignancies.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Fc Receptor-Like 3 (FCRL3)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB

purification

Purified through a protein A column, followed by peptide affinity purification.

recommended dilution

WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

FCRL3

dry ice

availability

Shipped within 5-10 working days.

alias

Fc receptor-like protein 3,MAIA,FCRH3,IFGP3,IRTA3,SPAP2,CD307c,Fc receptor homolog 3,IFGP family protein 3,Hifgp3

uniprot id

https://www.uniprot.org/uniprotkb/Q96P31

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