Fc Receptor-Like Protein 3 (FCRL3) Antibody
312€ (0.1 mg)
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935106861
info@markelab.com
name
Fc Receptor-Like Protein 3 (FCRL3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx347158
tested applications
FCM
Description
Fc Receptor-Like Protein 3 (FCRL3) Antibody is a Mouse Monoclonal Antibody against Fc Receptor-Like Protein 3 (FCRL3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Fc Receptor-Like Protein 3 (FCRL3) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | FCM: 1-4 μg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone ID | K645 |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q96P31 |
| Gene ID | 115352 |
| Alias | Fc receptor-like protein 3,MAIA,FCRH3,IFGP3,IRTA3,SPAP2,CD307c,Fc receptor homolog 3,IFGP family protein 3,Hifgp3 |
| Background | Antibody anti-FCRL3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Fc Receptor Like 3 (FCRL3) is expressed on B cells, regulatory T cells, and some natural killer cells, functioning as an immune checkpoint molecule. The presence of ITIMs in its structure supports its inhibitory role in immune regulation, particularly in dampening autoimmunity. FCRL3 polymorphisms have been linked to autoimmune diseases such as rheumatoid arthritis and type 1 diabetes, where genetic variants contribute to increased susceptibility. Collectively, the FCRL family represents a critical set of regulators for immune cell function, offering potential therapeutic targets for autoimmune disorders and B cell-related malignancies.
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Fc Receptor-Like 3 (FCRL3) Antibody
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.
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