Fc Receptor-Like Protein 4 (FCRL4) Antibody

Este producto es parte de FCRL - Fc receptor like
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Fc Receptor-Like Protein 4 (FCRL4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037262
tested applications
ELISA, WB, IHC

Description

Rabbit Polyclonal against the FCRL4 protein.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetFc Receptor-Like Protein 4 (FCRL4)
HostRabbit
ReactivityHuman
Recommended DilutionELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified by antigen affinity column chromatography.
Size 1100 µg
Size 21 mg
FormLyophilized
Tested ApplicationsELISA, WB, IHC
BufferPrior to lyophilization: 1% BSA and 0.02% NaN3.
AvailabilityShipped within 7-15 working days.
StorageStore at -20 °C. Avoid repeated freeze/thaw cycles.
Dry IceNo
AliasFc receptor-like protein 4,FCRH4,IGFP2,IRTA1,CD307d,FcR-like protein 4,FcRL4,IFGP family protein 2,hIFGP2
BackgroundAntibody anti-FCRL4
StatusRUO
NoteConcentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. -

Descripción

Fc Receptor Like 4 (FCRL4) is a transmembrane protein expressed on a subset of memory B cells, predominantly in mucosal and inflamed tissues. Unlike other Fc receptor-like proteins, FCRL4 has a distinct role in dampening B cell receptor (BCR) signaling. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail, allowing it to inhibit activation signals and antibody production. FCRL4 expression is often upregulated in chronic infections and autoimmune diseases, where it is associated with an exhausted B cell phenotype, potentially contributing to immune dysregulation and impaired humoral responses.
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