Fc Receptor-Like Protein 4 (FCRL4) Antibody (PE)

Este producto es parte de FCRL - Fc receptor like
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429€ (100 tests)

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935106861
info@markelab.com
name
Fc Receptor-Like Protein 4 (FCRL4) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx347175
tested applications
FCM

Description

Fc Receptor-Like Protein 4 (FCRL4) Antibody (PE) is a mouse monoclonal antibody against Fc Receptor-Like Protein 4 (FCRL4).

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetFc Receptor-Like Protein 4 (FCRL4)
HostMouse
ReactivityHuman
Recommended DilutionFCM: 10 μl/100 μl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user.
ClonalityMonoclonal
ConjugationPE
IsotypeIgG2a Kappa
Clone IDP633
Size 1100 tests
Tested ApplicationsFCM
BufferStabilizing PBS solution containing 15 mM sodium azide.
AvailabilityShipped within 5-12 working days.
StorageStore in the dark at 2-8°C. Avoid exposure to light. Do not freeze.
Dry IceNo
UniProt IDQ96PJ5
Gene ID83417
OMIM605876
AliasFc receptor-like protein 4,FCRH4,IGFP2,IRTA1,CD307d,FcR-like protein 4,FcRL4,IFGP family protein 2,hIFGP2
BackgroundAntibody anti-FCRL4
StatusRUO

Descripción

Fc Receptor Like 4 (FCRL4) is a transmembrane protein expressed on a subset of memory B cells, predominantly in mucosal and inflamed tissues. Unlike other Fc receptor-like proteins, FCRL4 has a distinct role in dampening B cell receptor (BCR) signaling. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail, allowing it to inhibit activation signals and antibody production. FCRL4 expression is often upregulated in chronic infections and autoimmune diseases, where it is associated with an exhausted B cell phenotype, potentially contributing to immune dysregulation and impaired humoral responses.
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