Fc Receptor-Like Protein 1 (FCRL1) Antibody
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935106861
info@markelab.com
Precio
250€ (80 µl)
Antibody anti-FCRL1
proveedor
Abbexareference
abx030308Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants.
Background
Fc Receptor Like 1 (FCRL1) is a transmembrane protein expressed primarily on B cells and is a member of the immunoglobulin superfamily. It plays a role in regulating B cell activation and immune responses. The cytoplasmic domain of FCRL1 contains both immunoreceptor tyrosine-based activation motifs (ITAMs) and immunoreceptor tyrosine-based inhibitory motifs (ITIMs), suggesting it can transmit both activating and inhibitory signals. Dysregulation of FCRL1 expression has been associated with autoimmune conditions like systemic lupus erythematosus (SLE), indicating its importance in immune tolerance and balance.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Fc Receptor-Like Protein 1 (FCRL1)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified through a protein A column, followed by peptide affinity purification.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
FCRL1
dry ice
No
availability
Shipped within 5-10 working days.
alias
Fc receptor-like protein 1FcR-like protein 1,FcRL1,Fc receptor homolog 1,FCRH1,IFGP1,IRTA5,CD307a
uniprot id
note
This product is for research use only.
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