Fc Receptor-Like Protein 4 (FCRL4) Antibody (FITC)

Este producto es parte de FCRL - Fc receptor like
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169€ (20 µg)

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935106861
info@markelab.com
name
Fc Receptor-Like Protein 4 (FCRL4) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx309174

Description

FCRL4 Antibody (FITC) is a Rabbit Polyclonal against FCRL4 conjugated to FITC.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetFc Receptor-Like Protein 4 (FCRL4)
HostRabbit
ReactivityHuman
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationFITC
IsotypeIgG
Purity> 95%
PurificationPurified by Protein G.
Size 120 µg
Size 250 µg
Size 3100 µg
Size 4200 µg
Size 51 mg
FormLiquid
Buffer0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDQ96PJ5
Gene ID83417
NCBI AccessionNP_112572.1, NM_031282.2
OMIM605876
AliasFc receptor-like protein 4,FCRH4,IGFP2,IRTA1,CD307d,FcR-like protein 4,FcRL4,IFGP family protein 2,hIFGP2
BackgroundAntibody anti-FCRL4
StatusRUO

Descripción

Fc Receptor Like 4 (FCRL4) is a transmembrane protein expressed on a subset of memory B cells, predominantly in mucosal and inflamed tissues. Unlike other Fc receptor-like proteins, FCRL4 has a distinct role in dampening B cell receptor (BCR) signaling. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail, allowing it to inhibit activation signals and antibody production. FCRL4 expression is often upregulated in chronic infections and autoimmune diseases, where it is associated with an exhausted B cell phenotype, potentially contributing to immune dysregulation and impaired humoral responses.
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