PTGR - Prostaglandin receptor | Elisa - Clia - Antibody - Protein

Background:

The Prostaglandin Receptor (PTGR) family encompasses various subtypes, each playing distinct roles in mediating the effects of prostaglandins. PTGRs are G protein-coupled receptors (GPCRs) that respond to prostaglandins, lipid signaling molecules with diverse physiological functions.

PTGRs are expressed in multiple tissues and cell types, influencing inflammation, vascular tone, pain perception, and other processes. PTGRs are activated by various prostaglandins, including prostaglandin E2 (PGE2), prostaglandin D2 (PGD2), prostaglandin F2α (PGF2α), prostaglandin I2 (PGI2), and thromboxane A2 (TXA2).In summary, the Prostaglandin Receptor (PTGR) family, including subtypes such as PTGDR, PTGDR2, PTGER1, PTGER2, PTGER3, PTGER4, and PTGFR, plays critical roles in mediating the effects of prostaglandins in various physiological processes. Dysregulation of PTGR signaling is implicated in inflammatory diseases, cardiovascular disorders, and pain disorders, highlighting their therapeutic potential as targets for pharmacological intervention.

Structural Features:

• Typical GPCR structure with seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus.
• Ligand binding induces conformational changes, initiating downstream signaling pathways.

Subtypes:

• PTGDR: Receptor for prostaglandin D2.
• PTGDR2: Another receptor for prostaglandin D2, possibly with distinct signaling properties.
• PTGER1, PTGER2, PTGER3, PTGER4: Receptors for prostaglandin E2, each with different tissue distributions and signaling cascades.
• PTGFR: Receptor for prostaglandin F2α, involved in smooth muscle contraction and other physiological processes.

Physiological Functions:

• Inflammatory Responses: Regulate immune cell activation, cytokine production, and leukocyte chemotaxis.
• Vascular Regulation: Influence vascular tone, endothelial function, and blood flow regulation.
• Pain Perception: Modulate neuronal excitability, synaptic transmission, and sensitization of pain pathways.

Clinical Implications:

• Inflammatory Diseases: Implicated in conditions like rheumatoid arthritis, inflammatory bowel disease, and asthma.
• Cardiovascular Disorders: Associated with hypertension, atherosclerosis, and thrombosis.
• Pain Disorders: Potential targets for analgesic therapy in acute and chronic pain conditions.

Therapeutic Potential:

• Anti-inflammatory Therapy: Targeting PTGR signaling pathways for the treatment of inflammatory diseases.
• Cardiovascular Protection: Modulation of PTGR activity for cardiovascular protection and hypertension management.
• Pain Management: Development of PTGR-selective agonists or antagonists for pain management.