Rat Prostaglandin E Receptor 1 (PTGER1) ELISA Kit

Este producto es parte de PTGR - Prostaglandin receptor
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715€ (96 tests)

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935106861
info@markelab.com
name
Rat Prostaglandin E Receptor 1 (PTGER1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx538336
tested applications
ELISA

Description

Rat Prostaglandin E Receptor 1 (PTGER1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Prostaglandin E2 receptor EP1 subtype concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Prostaglandin E Receptor 1 (PTGER1)
Reactivity
Rat
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
P70597
Alias
PTGER1,EP1 prostanoid receptor,PGE receptor EP1 subtype,prostanoid EP1 receptor,prostaglandin E receptor 1 (subtype EP1)
Background
Elisa kits for PTGER1
Status
RUO
Note
Validity: The validity for this kit is 6 months.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

PTGER1, or EP1, is a G protein-coupled receptor activated by prostaglandin E2 (PGE2), a key mediator of inflammation, pain, and fever. PTGER1 couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and modulating downstream signaling pathways that regulate smooth muscle contraction, pain perception, and inflammation. PTGER1 is expressed in smooth muscle cells, neurons, and immune cells, where it plays a critical role in pain sensitization, gastric acid secretion, and vascular responses. Activation of PTGER1 enhances nociceptive signaling in peripheral sensory neurons, contributing to inflammatory pain and hyperalgesia. In the gastrointestinal system, PTGER1 regulates acid secretion and mucosal protection, while in the vasculature, it mediates vasoconstriction. Dysregulation of PTGER1 is associated with inflammatory diseases, pain disorders, and gastric ulcers. PTGER1 antagonists are being explored for treating inflammatory pain, arthritis, and gastric acid-related conditions by modulating PGE2-induced effects on inflammation and nociception.

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