Prostaglandin E Receptor 1 (PTGER1) Antibody
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935106861
info@markelab.com
Precio
260€ (50 µl)
Antibody anti-PTGER1
proveedor
Abbexareference
abx242377Tested Applications
ELISA, WBreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
PTGER1 Antibody is a Rabbit Polyclonal against PTGER1.
Background
PTGER1, or EP1, is a G protein-coupled receptor activated by prostaglandin E2 (PGE2), a key mediator of inflammation, pain, and fever. PTGER1 couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and modulating downstream signaling pathways that regulate smooth muscle contraction, pain perception, and inflammation. PTGER1 is expressed in smooth muscle cells, neurons, and immune cells, where it plays a critical role in pain sensitization, gastric acid secretion, and vascular responses. Activation of PTGER1 enhances nociceptive signaling in peripheral sensory neurons, contributing to inflammatory pain and hyperalgesia. In the gastrointestinal system, PTGER1 regulates acid secretion and mucosal protection, while in the vasculature, it mediates vasoconstriction. Dysregulation of PTGER1 is associated with inflammatory diseases, pain disorders, and gastric ulcers. PTGER1 antagonists are being explored for treating inflammatory pain, arthritis, and gastric acid-related conditions by modulating PGE2-induced effects on inflammation and nociception.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Prostaglandin E Receptor 1 (PTGER1)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Antigen Affinity Chromatography.
recommended dilution
ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
size 1
50 µl
size 2
100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
PTGER1
dry ice
No
availability
Shipped within 5-10 working days.
alias
PTGER1,EP1 prostanoid receptor,PGE receptor EP1 subtype,prostanoid EP1 receptor,prostaglandin E receptor 1 (subtype EP1)
uniprot id
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