Prostaglandin E Receptor 1 (PTGER1) Antibody
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Description
PTGER1 Antibody is a Rabbit Polyclonal antibody against PTGER1. The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Prostaglandin E Receptor 1 (PTGER1) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P34995 |
| Gene ID | 5731 |
| Alias | PTGER1,EP1 prostanoid receptor,PGE receptor EP1 subtype,prostanoid EP1 receptor,prostaglandin E receptor 1 (subtype EP1) |
| Background | Antibody anti-PTGER1 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
PTGER1, or EP1, is a G protein-coupled receptor activated by prostaglandin E2 (PGE2), a key mediator of inflammation, pain, and fever. PTGER1 couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and modulating downstream signaling pathways that regulate smooth muscle contraction, pain perception, and inflammation. PTGER1 is expressed in smooth muscle cells, neurons, and immune cells, where it plays a critical role in pain sensitization, gastric acid secretion, and vascular responses. Activation of PTGER1 enhances nociceptive signaling in peripheral sensory neurons, contributing to inflammatory pain and hyperalgesia. In the gastrointestinal system, PTGER1 regulates acid secretion and mucosal protection, while in the vasculature, it mediates vasoconstriction. Dysregulation of PTGER1 is associated with inflammatory diseases, pain disorders, and gastric ulcers. PTGER1 antagonists are being explored for treating inflammatory pain, arthritis, and gastric acid-related conditions by modulating PGE2-induced effects on inflammation and nociception.
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Prostaglandin E Receptor 1 (PTGER1) Antibody
PTGER1 Antibody is a Rabbit Polyclonal antibody against PTGER1. The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.
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