Prostaglandin E Receptor 4 (PTGER4) Antibody
169€ (20 µg)
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Name
Prostaglandin E Receptor 4 (PTGER4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx338887
Tested Applications
ELISA, WB, IF/ICC
Description
PTGER4 Antibody is a Rabbit Polyclonal against PTGER4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Prostaglandin E Receptor 4 (PTGER4) Immunogen: Recombinant Human Prostaglandin E2 receptor EP4 subtype protein (354-472AA). |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | WB: 1/500 - 1/5000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35408 |
| Gene ID | 5734 |
| Alias | PTGER4,EP2,PGE receptor EP4 subtype,prostanoid EP4 receptor,EP4R |
| Background | Antibody anti-PTGER4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTGER4, or EP4, is a G protein-coupled receptor activated by prostaglandin E2 (PGE2), playing a key role in inflammation, immune regulation, and tissue homeostasis. EP4 primarily couples to Gs proteins, stimulating adenylate cyclase, increasing cAMP levels, and activating downstream signaling pathways such as PKA, PI3K/Akt, and β-arrestin. EP4 is widely expressed in immune cells, endothelial cells, and epithelial tissues, where it mediates vasodilation, bone remodeling, and anti-inflammatory effects. In the immune system, EP4 regulates T cell differentiation, macrophage activity, and cytokine production, contributing to inflammation resolution. Dysregulation of EP4 signaling is implicated in chronic inflammatory diseases, autoimmune disorders, and cancer, where EP4 activation promotes angiogenesis, immune evasion, and tumor growth. EP4 agonists are being investigated for conditions like osteoarthritis and ulcerative colitis due to their anti-inflammatory effects, while EP4 antagonists are explored for cancer therapy and cardiovascular diseases, where modulation of PGE2 responses holds therapeutic potential.
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