Rat Prostaglandin D2 Receptor 2 (PTGDR2) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PTGDR2
proveedor
Abbexareference
abx538139Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Prostaglandin D2 Receptor 2 (PTGDR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Prostaglandin D2 receptor 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PTGDR2, also known as DP2 or CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), is a G protein-coupled receptor that binds prostaglandin D2 (PGD2). Unlike PTGDR, PTGDR2 couples to Gi proteins, inhibiting adenylate cyclase and promoting calcium mobilization, leading to chemotaxis, immune activation, and inflammation. PTGDR2 is highly expressed in Th2 cells, eosinophils, basophils, and innate lymphoid cells (ILC2), where it mediates allergic inflammation, cytokine release, and recruitment of immune cells to inflamed tissues. PTGDR2 is a key player in Th2-driven diseases, including asthma, allergic rhinitis, and chronic obstructive pulmonary disease (COPD). Dysregulation of PTGDR2 signaling contributes to chronic airway inflammation, tissue remodeling, and eosinophilic responses. PTGDR2 antagonists are being developed as novel therapies for allergic asthma, atopic dermatitis, and other Th2-mediated inflammatory conditions by inhibiting PGD2-dependent immune cell activation.
Características del producto
category
ELISA Kits
immunogen target
Prostaglandin D2 Receptor 2 (PTGDR2)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
PTGDR2,CRTH2,CD294,G protein-coupled receptor 44, prostaglandin D2 receptor 2,PGD2 receptor,Gpr44,DL1R, DP2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PTGDR2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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