anti- PTGER3 antibody
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Description
Receptor for prostaglandin E2(PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | prostaglandin E receptor 3(subtype EP3) |
| Host | Rabbit |
| Reactivity | human,rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 55 kDa, 70 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P43115 |
| Gene ID | 5733 |
| Alias | PTGER3,PGE receptor EP3 subtype,prostaglandin E receptor 3,prostanoid EP3 receptor,EP3,EP3-I,EP3-II,EP3-III,EP3-IV,EP3-VI,EP3e,PGE2-R |
| Background | Antibody anti-PTGER3 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
PTGER3, or EP3, is a G protein-coupled receptor activated by prostaglandin E2 (PGE2). Unlike other PGE2 receptors, EP3 exhibits unique signaling versatility, coupling to Gi, Gq, and Gs proteins to mediate diverse cellular responses. Activation of EP3 inhibits adenylate cyclase through Gi proteins, reduces cAMP levels, and enhances calcium mobilization via Gq pathways. EP3 is widely expressed in smooth muscle, immune cells, and neurons, where it regulates fever, gastric acid secretion, and smooth muscle contraction. EP3 plays a critical role in febrile responses by mediating PGE2-induced fever through its action in the hypothalamus. In the gastrointestinal tract, EP3 protects the gastric mucosa by reducing acid secretion and promoting mucus production. Dysregulation of EP3 contributes to fever, gastric ulcers, and vascular dysfunction. EP3 antagonists are being investigated for conditions like inflammation and fever, while agonists are explored for their protective effects in gastric ulceration and smooth muscle-related disorders.
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anti- PTGER3 antibody
Receptor for prostaglandin E2(PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems(By similarity).
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anti- PTGER3 antibody
Receptor for prostaglandin E2(PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems(By similarity).
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