Prostaglandin F Receptor (PTGFR) Antibody
273€ (200 µl)
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935106861
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name
Prostaglandin F Receptor (PTGFR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433201
tested applications
P-ELISA
Description
PTGFR Antibody is a Goat Polyclonal antibody against PTGFR.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Prostaglandin F Receptor (PTGFR) |
| Host | Goat |
| Recommended Dilution | P-ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 5737 |
| NCBI Accession | NP_000950.1 |
| Alias | PTGFR,PF2AR,PGF receptor,PGF2 alpha receptor,prostaglandin F receptor,prostaglandin F2-alpha receptor,prostaglandin F receptor,FP |
| Background | Antibody anti-PTGFR |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Prostaglandin F2-Alpha Receptor (PTGFR), also known as the FP receptor, is a G protein-coupled receptor activated by prostaglandin F2-alpha (PGF2α), a lipid-derived signaling molecule involved in reproductive, vascular, and inflammatory processes. PTGFR primarily couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium, and stimulating downstream signaling pathways, including Rho-kinase and MAPK. PTGFR is widely expressed in the uterus, corpus luteum, vascular smooth muscle, and ocular tissues, where it regulates smooth muscle contraction, luteolysis, and intraocular pressure. In the female reproductive system, PTGFR mediates uterine contraction during labor and luteolysis, the regression of the corpus luteum, which is essential for the estrous cycle. Clinically, FP receptor agonists such as latanoprost and bimatoprost are widely used to treat glaucoma by reducing intraocular pressure through enhanced aqueous humor outflow. Dysregulation of PTGFR signaling is associated with preterm labor, dysmenorrhea, and elevated intraocular pressure. Due to its role in smooth muscle regulation and ocular function, PTGFR remains a critical therapeutic target for reproductive and ophthalmic disorders.
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