Prostaglandin D2 Receptor 2 (PTGDR2) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
Prostaglandin D2 Receptor 2 (PTGDR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx325488
tested applications
ELISA, WB
Description
PTGDR2 Antibody is a Rabbit Polyclonal against PTGDR2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Prostaglandin D2 Receptor 2 (PTGDR2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y5Y4 |
| Gene ID | 11251 |
| Alias | PTGDR2,CRTH2,CD294,G protein-coupled receptor 44, prostaglandin D2 receptor 2,PGD2 receptor,Gpr44,DL1R, DP2 |
| Background | Antibody anti-PTGDR2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PTGDR2, also known as DP2 or CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), is a G protein-coupled receptor that binds prostaglandin D2 (PGD2). Unlike PTGDR, PTGDR2 couples to Gi proteins, inhibiting adenylate cyclase and promoting calcium mobilization, leading to chemotaxis, immune activation, and inflammation. PTGDR2 is highly expressed in Th2 cells, eosinophils, basophils, and innate lymphoid cells (ILC2), where it mediates allergic inflammation, cytokine release, and recruitment of immune cells to inflamed tissues. PTGDR2 is a key player in Th2-driven diseases, including asthma, allergic rhinitis, and chronic obstructive pulmonary disease (COPD). Dysregulation of PTGDR2 signaling contributes to chronic airway inflammation, tissue remodeling, and eosinophilic responses. PTGDR2 antagonists are being developed as novel therapies for allergic asthma, atopic dermatitis, and other Th2-mediated inflammatory conditions by inhibiting PGD2-dependent immune cell activation.
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