Prostaglandin E2 Receptor EP3 Subtype (PTGER3) Antibody
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Description
PTGER3 Antibody is a Rabbit Polyclonal against PTGER3.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Prostaglandin E2 Receptor EP3 Subtype (PTGER3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43115 |
| Gene ID | 5733 |
| Alias | PTGER3,PGE receptor EP3 subtype,prostaglandin E receptor 3,prostanoid EP3 receptor,EP3,EP3-I,EP3-II,EP3-III,EP3-IV,EP3-VI,EP3e,PGE2-R |
| Background | Antibody anti-PTGER3 |
| Status | RUO |
Descripción
PTGER3, or EP3, is a G protein-coupled receptor activated by prostaglandin E2 (PGE2). Unlike other PGE2 receptors, EP3 exhibits unique signaling versatility, coupling to Gi, Gq, and Gs proteins to mediate diverse cellular responses. Activation of EP3 inhibits adenylate cyclase through Gi proteins, reduces cAMP levels, and enhances calcium mobilization via Gq pathways. EP3 is widely expressed in smooth muscle, immune cells, and neurons, where it regulates fever, gastric acid secretion, and smooth muscle contraction. EP3 plays a critical role in febrile responses by mediating PGE2-induced fever through its action in the hypothalamus. In the gastrointestinal tract, EP3 protects the gastric mucosa by reducing acid secretion and promoting mucus production. Dysregulation of EP3 contributes to fever, gastric ulcers, and vascular dysfunction. EP3 antagonists are being investigated for conditions like inflammation and fever, while agonists are explored for their protective effects in gastric ulceration and smooth muscle-related disorders.
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Receptor for prostaglandin E2(PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems(By similarity).
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Receptor for prostaglandin E2(PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems(By similarity).
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