Family main features
The UNC5 family of netrin receptors is crucial for mediating cell guidance during development. These receptors were first identified in the nematode Caenorhabditis elegans as part of a genetic pathway that guides neuronal migration and axon pathfinding. In vertebrates, the UNC5 family consists of four members: UNC5A, UNC5B, UNC5C, and UNC5D. These receptors are primarily involved in the processes of cell migration, axon guidance, and apoptosis through their interactions with netrin-1, a secreted protein that serves as a guidance cue for developing neurons. The balance between attractive and repulsive guidance cues provided by netrin-1 and its receptors, including UNC5 and the DCC (Deleted in Colorectal Cancer) family, orchestrates the precise wiring of the nervous system.
UNC5 receptors are type I transmembrane proteins composed of several distinct domains:
The UNC5 family of receptors is classified into four main subtypes, each with unique and overlapping roles in development and disease:
UNC5 receptors primarily mediate repulsive guidance cues in response to netrin-1. When netrin-1 binds to UNC5, it typically results in the repulsion of growth cones, steering developing axons away from regions expressing high levels of netrin-1. This mechanism ensures the proper wiring of neural circuits by preventing axons from entering inappropriate target areas.
In addition to their roles in axon guidance, UNC5 receptors are involved in:
Dysregulation of UNC5 receptors and their signaling pathways is implicated in various pathological conditions:
UNC5 receptors are essential components of the netrin-1 signaling pathway, mediating key processes in neuronal development, cell migration, apoptosis, and angiogenesis. Their roles in health and disease underscore the importance of precise regulation of guidance cues during development and tissue homeostasis. Dysregulation of UNC5 signaling pathways is implicated in various pathological conditions, including cancer, neurodegenerative diseases, and congenital disorders. Understanding the molecular mechanisms underlying UNC5 receptor function and regulation provides valuable insights into potential therapeutic targets for these conditions. The diverse and complex roles of UNC5 receptors highlight their significance in maintaining cellular and tissue integrity throughout life.
unc-5 netrin receptor A (UNC5A)
UNC5H1,Protein unc-5 homolog 1,Protein unc-5 homolog A,Netrin receptor UNC5A
unc-5 netrin receptor B (UNC5B)
UNC5H2,p53RDL1,Protein unc-5 homolog 2,Protein unc-5 homolog B,p53-regulated receptor for death and life protein 1,Netrin receptor UNC5B
unc-5 netrin receptor C (UNC5C)
UNC5H3,Protein unc-5 homolog 3,Protein unc-5 homolog C,Netrin receptor UNC5C
unc-5 netrin receptor D (UNC5D)
Unc5h4,PRO34692,Protein unc-5 homolog 4,Protein unc-5 homolog D,Netrin receptor UNC5D
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (ELISA Kits, Primary Antibodies, Proteins and Peptides) relacionados con UNC5 - unc-5 netrin receptor
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 41 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | UNC5C | abx520696 | Chicken Netrin receptor UNC5C (UNC5C) ELISA Kit | Chicken | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q7T2Z5 | RUO | ||
FineTest | UNC5B | EH4330 | Human UNC5B(Netrin Receptor UNC5B) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | Q8IZJ1 | RUO | ||
FineTest | UNC5C | EH2373 | Human UNC5C(Netrin receptor UNC5C) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | O95185 | RUO | ||
Abbexa | UNC5A | abx384131 | Human Netrin receptor UNC5A (UNC5A) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q6ZN44 | RUO |
Abbexa | UNC5B | abx259097 | Human Netrin receptor UNC5B (UNC5B) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.19 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | UNC5C | abx251732 | Human Netrin receptor UNC5C (UNC5C) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O95185 | RUO | |
Abbexa | UNC5D | abx384133 | Human Netrin receptor UNC5D (UNC5D) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.188 ng/ml | 687.5 | 96 tests | Q6UXZ4 | RUO |
Abbexa | UNC5A | abx552620 | Mouse Netrin receptor UNC5A (UNC5A) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8K1S4 | RUO | |
Abbexa | UNC5B | abx552623 | Mouse Netrin receptor UNC5B (UNC5B) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8K1S3 | RUO | |
Abbexa | UNC5C | abx520698 | Mouse Netrin receptor UNC5C (UNC5C) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 687.5 | 96 tests | O08747 | RUO | |
Abbexa | UNC5D | abx552626 | Mouse Netrin receptor UNC5D (UNC5D) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8K1S2 | RUO | ||
Abbexa | UNC5A | abx552621 | Rat Netrin receptor UNC5A (UNC5A) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O08721 | RUO | |
Abbexa | UNC5B | abx552624 | Rat Netrin receptor UNC5B (UNC5B) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O08722 | RUO | |
Abbexa | UNC5C | abx520699 | Rat Netrin receptor UNC5C (UNC5C) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 18 pg/ml | 687.5 | 96 tests | Q761X5 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | UNC5A | FNab09261 | anti- UNC5A antibody | human | polyclonal | Rabbit | unc-5 homolog A | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q6ZN44 | RUO | |
FineTest | UNC5A | FNab09260 | anti- UNC5A antibody | human | polyclonal | Rabbit | unc-5 homolog A | IgG | Unconjugated | ELISA, WB | 100µg | Q6ZN44 | RUO | |
FineTest | UNC5C | FNab09263 | anti- UNC5C-Specific antibody | human | polyclonal | Rabbit | unc-5 homolog C(C. elegans) | IgG | Unconjugated | ELISA, WB | 100µg | O95185 | RUO | |
FineTest | UNC5D | FNab09264 | anti- UNC5D-Specific antibody | human | polyclonal | Rabbit | unc-5 homolog D(C. elegans) | IgG | Unconjugated | ELISA, WB | 100µg | Q6UXZ4 | RUO | |
Abbexa | UNC5A | abx239260 | Netrin Receptor UNC5A (UNC5A) Antibody | Human | Polyclonal | Rabbit | Netrin Receptor UNC5A (UNC5A) | Unconjugated | ELISA, WB | 350 | 100 µg | Q6ZN44 | RUO | |
Abbexa | UNC5A | abx219255 | Netrin Receptor UNC5A (UNC5A) Antibody | Human | Polyclonal | Rabbit | Netrin Receptor UNC5A (UNC5A) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q6ZN44 | RUO | |
Abbexa | UNC5B | abx334202 | Netrin receptor UNC5B (UNC5B) Antibody | Human | Polyclonal | Rabbit | Netrin receptor UNC5B (UNC5B) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q8IZJ1 | RUO | |
Abbexa | UNC5B | abx336736 | Netrin receptor UNC5B (UNC5B) Antibody (HRP) | Human | Polyclonal | Rabbit | Netrin receptor UNC5B (UNC5B) | HRP | ELISA | 162.5 | 20 µg | Q8IZJ1 | RUO | |
Abbexa | UNC5B | abx431030 | Netrin Receptor UNC5B (UNC5B) Antibody | Human | Polyclonal | Goat | Netrin Receptor UNC5B (UNC5B) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | UNC5B | abx336738 | Netrin receptor UNC5B (UNC5B) Antibody (Biotin) | Human | Polyclonal | Rabbit | Netrin receptor UNC5B (UNC5B) | Biotin | ELISA | 162.5 | 20 µg | Q8IZJ1 | RUO | |
Abbexa | UNC5B | abx336737 | Netrin receptor UNC5B (UNC5B) Antibody (FITC) | Human | Polyclonal | Rabbit | Netrin receptor UNC5B (UNC5B) | FITC | 162.5 | 20 µg | Q8IZJ1 | RUO | ||
Abbexa | UNC5B | abx375613 | Netrin Receptor UNC5B (Unc5b) Antibody | Human | Polyclonal | Rabbit | Netrin Receptor UNC5B (Unc5b) | Unconjugated | ELISA, WB | 337.5 | 100 µg | Q8IZJ1 | RUO | |
Abbexa | UNC5C | abx031284 | Netrin Receptor UNC5C (UNC5C) Antibody | Human | Polyclonal | Rabbit | Netrin Receptor UNC5C (UNC5C) | Unconjugated | ELISA, WB | 281.25 | 80 µl | O95185 | RUO | |
Abbexa | UNC5C | abx033065 | Netrin Receptor UNC5C (UNC5C) Antibody | Human | Polyclonal | Rabbit | Netrin Receptor UNC5C (UNC5C) | Unconjugated | ELISA, WB, IHC, FCM | 281.25 | 80 µl | O95185 | RUO | |
Abbexa | UNC5C | abx431697 | Netrin Receptor UNC5C (UNC5C) Antibody | Human | Polyclonal | Goat | Netrin Receptor UNC5C (UNC5C) | Unconjugated | P-ELISA, IHC, IF/ICC | 387.5 | 200 µl | RUO | ||
Abbexa | UNC5C | abx239263 | UNC5C-Specific Antibody | Human | Polyclonal | Rabbit | UNC5C-Specific | Unconjugated | ELISA, WB | 350 | 100 µg | O95185 | RUO | |
Abbexa | UNC5C | abx375614 | Netrin Receptor UNC5C (UNC5C) Antibody | Human | Polyclonal | Rabbit | Netrin Receptor UNC5C (UNC5C) | Unconjugated | ELISA, WB | 337.5 | 100 µg | O95185 | RUO | |
Abbexa | UNC5D | abx027189 | Netrin Receptor UNC5D (UNC5D) Antibody | Human | Polyclonal | Rabbit | Netrin Receptor UNC5D (UNC5D) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q6UXZ4 | RUO | |
Abbexa | UNC5D | abx346616 | Netrin receptor UNC5D (UNC5D) Antibody (FITC) | Human | Polyclonal | Rabbit | Netrin receptor UNC5D (UNC5D) | FITC | 162.5 | 20 µg | Q6UXZ4 | RUO | ||
Abbexa | UNC5D | abx346615 | Netrin receptor UNC5D (UNC5D) Antibody (HRP) | Human | Polyclonal | Rabbit | Netrin receptor UNC5D (UNC5D) | HRP | ELISA | 162.5 | 20 µg | Q6UXZ4 | RUO | |
Abbexa | UNC5D | abx346617 | Netrin receptor UNC5D (UNC5D) Antibody (Biotin) | Human | Polyclonal | Rabbit | Netrin receptor UNC5D (UNC5D) | Biotin | ELISA | 162.5 | 20 µg | Q6UXZ4 | RUO | |
Abbexa | UNC5D | abx346614 | Netrin receptor UNC5D (UNC5D) Antibody | Human | Polyclonal | Rabbit | Netrin receptor UNC5D (UNC5D) | Unconjugated | ELISA, IF/ICC | 162.5 | 20 µg | Q6UXZ4 | RUO | |
Abbexa | UNC5D | abx375615 | Netrin Receptor UNC5D (UNC5D) Antibody | Human | Polyclonal | Rabbit | Netrin Receptor UNC5D (UNC5D) | Unconjugated | ELISA, WB | 337.5 | 100 µg | Q6UXZ4 | RUO | |
Abbexa | UNC5D | abx239264 | UNC5D-Specific Antibody | Human | Polyclonal | Rabbit | UNC5D-Specific | Unconjugated | ELISA, WB | 350 | 100 µg | Q6UXZ4 | RUO | |
Abbexa | UNC5B | abx431031 | Netrin Receptor UNC5B (Unc5b) Antibody | Mouse | Polyclonal | Goat | Netrin Receptor UNC5B (Unc5b) | Unconjugated | P-ELISA | 250 | 200 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | UNC5B | abx691027 | Rat Netrin Receptor UNC5B (UNC5B) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | RUO | ||
Abbexa | UNC5B | abx680576 | Rat Netrin receptor UNC5B (UNC5B) Protein | Rat | Recombinant | Unconjugated | 225 | 2 µg | RUO |
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