Netrin Receptor UNC5D (UNC5D) Antibody
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Description
UNC5D is receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Netrin Receptor UNC5D (UNC5D) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6UXZ4 |
| Alias | Unc5h4,PRO34692,Protein unc-5 homolog 4,Protein unc-5 homolog D,Netrin receptor UNC5D |
| Background | Antibody anti-UNC5D |
| Status | RUO |
Descripción
unc-5 netrin receptor D (UNC5D) operates as a dependence receptor for netrin-1, significantly contributing to axonal guidance, vascular organization, and cellular homeostasis. In the nervous system, UNC5D directs the repulsive migration of axons and neuronal processes, facilitating the formation of precise neural circuits during embryogenesis. Its function extends beyond the nervous system, as it modulates cell migration, adhesion, and apoptosis in a variety of tissue types. As a tumor suppressor, UNC5D induces apoptosis in the absence of netrin-1, acting as a checkpoint to inhibit malignant cell survival and growth. Dysregulation of UNC5D expression or signaling has been implicated in various cancers, including colorectal and lung carcinomas, where its loss allows tumor cells to evade apoptosis and metastasize. Additionally, UNC5D is involved in vascular development, where it ensures the proper formation and organization of blood vessels by mediating endothelial cell migration and positioning. Its expression is tightly regulated, and disruptions in its signaling pathways are linked to pathological conditions, such as cancer progression and abnormal angiogenesis. The multifunctional roles of UNC5D make it an attractive target for cancer therapy and developmental biology research.
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UNC5D, also named as KIAA1777 and UNC5H4, belongs to the unc-5 family. It is a receptor for netrin. It may be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. The antibody is specific to UNC5D.
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UNC5D is receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).
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