Rat Netrin Receptor UNC5B (UNC5B) Protein

Este producto es parte de UNC5 - unc-5 netrin receptor
Product Graph
1079€ (100 µg)

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935106861
info@markelab.com
name
Rat Netrin Receptor UNC5B (UNC5B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691027
tested applications
SDS-PAGE

Description

Rat UNC5B Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat UNC5B (NP_071543.1) (Met1-Asp373) was expressed with the Fc region of human IgG1 at the C-terminus.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
UNC5B
Host
HEK293 cells
Origin
Rat
Observed MW
Molecular Weight: 65.7 kDa
Sequence Fragment: Met1-Asp373
Tag: C-terminal Fc tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 85% (SDS-PAGE)
Size 1
100 µg
Form
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_071543.1
Alias
UNC5H2,p53RDL1,Protein unc-5 homolog 2,Protein unc-5 homolog B,p53-regulated receptor for death and life protein 1,Netrin receptor UNC5B
Background
Protein UNC5B
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

unc-5 netrin receptor B (UNC5B) acts as a receptor for netrin-1, orchestrating key cellular processes like axonal guidance and vascular development. UNC5B ensures proper vascular and neuronal organization by transmitting repellent cues that direct cellular movements. In endothelial cells, UNC5B is vital for angiogenesis, controlling endothelial migration and sprouting. Beyond developmental contexts, UNC5B is implicated in tumor suppression through apoptosis activation in netrin-1’s absence, akin to its role as a dependence receptor. Dysregulation of UNC5B has been linked to pathological angiogenesis and malignancies, highlighting its dual importance in both developmental and pathological processes.
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