anti- UNC5A antibody
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Description
Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | unc-5 homolog A |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 93 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6ZN44 |
| Gene ID | 90249 |
| Alias | UNC5H1,Protein unc-5 homolog 1,Protein unc-5 homolog A,Netrin receptor UNC5A |
| Background | Antibody anti-UNC5A |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
unc-5 netrin receptor A (UNC5A) functions as a dependence receptor, primarily influencing axonal guidance and neural development in response to netrin-1. It mediates repulsive signals, steering neuronal processes during embryogenesis to ensure correct nervous system wiring. Additionally, UNC5A contributes to tissue morphogenesis by regulating cell adhesion and migration. Its role extends beyond neural development to tumor suppression, as its expression mediates apoptosis in the absence of netrin-1. Aberrant regulation of UNC5A has been associated with cancer progression, where its loss can enable evasion of programmed cell death, leading to unchecked tumor growth and metastasis.
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