Netrin Receptor UNC5A (UNC5A) Antibody
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Description
UNC5A Antibody is a Rabbit Polyclonal against UNC5A.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Netrin Receptor UNC5A (UNC5A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6ZN44 |
| Gene ID | 90249 |
| OMIM | 607869 |
| Alias | UNC5H1,Protein unc-5 homolog 1,Protein unc-5 homolog A,Netrin receptor UNC5A |
| Background | Antibody anti-UNC5A |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
unc-5 netrin receptor A (UNC5A) functions as a dependence receptor, primarily influencing axonal guidance and neural development in response to netrin-1. It mediates repulsive signals, steering neuronal processes during embryogenesis to ensure correct nervous system wiring. Additionally, UNC5A contributes to tissue morphogenesis by regulating cell adhesion and migration. Its role extends beyond neural development to tumor suppression, as its expression mediates apoptosis in the absence of netrin-1. Aberrant regulation of UNC5A has been associated with cancer progression, where its loss can enable evasion of programmed cell death, leading to unchecked tumor growth and metastasis.
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