Chicken Netrin receptor UNC5C (UNC5C) ELISA Kit

Product specifications

ELISA Kits

Netrin receptor UNC5C (UNC5C)

Chicken

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-12 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q7T2Z5

UNC5H3,Protein unc-5 homolog 3,Protein unc-5 homolog C,Netrin receptor UNC5C

Elisa kits for UNC5C

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

unc-5 netrin receptor C (UNC5C) functions as a dependence receptor that mediates cellular responses to the presence or absence of netrin-1. UNC5C is critically involved in guiding axonal migration and positioning during neural development, playing a pivotal role in organizing the central and peripheral nervous systems. It primarily facilitates repulsive guidance signals, ensuring neurons and axons navigate away from inappropriate regions, thus contributing to the precision of neural circuit formation. Apart from its neural guidance role, UNC5C is implicated in maintaining tissue integrity by regulating cell adhesion and polarity. Its tumor suppressor function is mediated by the induction of apoptosis when netrin-1 is absent, which prevents uncontrolled cellular proliferation and migration. This receptor’s expression and function are often disrupted in cancers, where loss of UNC5C is linked to enhanced tumor invasiveness and resistance to programmed cell death. Furthermore, UNC5C plays roles in vascular development, ensuring proper endothelial cell organization and angiogenesis. Dysfunction of UNC5C signaling is also associated with neurodegenerative conditions, making it a subject of interest for therapeutic interventions targeting neural and oncological disorders.

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UNC5C, also named as UNC5H3, belongs to the unc-5 family. It is a receptor for netrin required for axon guidance. It mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. The antibody is specific to UNC5C.

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Netrin Receptor UNC5C (UNC5C) Antibody

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

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