Family main features
The SHC (Src Homology 2 domain-containing) adaptor protein is a pivotal component in signal transduction pathways that mediate cellular responses to various growth factors, hormones, and cytokines. SHC proteins play a critical role in linking receptor tyrosine kinases (RTKs) to downstream signaling pathways, particularly the Ras/MAPK pathway. This pathway is essential for regulating cell proliferation, differentiation, survival, and migration. There are three main isoforms of SHC: p46^SHC, p52^SHC, and p66^SHC, each encoded by the SHC1 gene and contributing to different aspects of cellular signaling.
SHC proteins share a common modular structure that includes several key domains:
SHC proteins are classified based on their size and specific functions:
SHC adaptor proteins are integral to various signaling pathways:
Aberrant SHC signaling is associated with various diseases:
SHC adaptor proteins are key mediators of signal transduction, linking activated receptor tyrosine kinases to downstream signaling pathways that regulate cell growth, differentiation, survival, and metabolism. Their modular structure, comprising PTB, CH1, and SH2 domains, enables them to interact with various signaling molecules and coordinate complex cellular responses. Dysregulation of SHC proteins is associated with several pathological conditions, including cancer, cardiovascular diseases, and metabolic disorders, highlighting their importance in maintaining cellular homeostasis. Understanding the precise roles and mechanisms of SHC proteins in these processes offers potential therapeutic avenues for treating related diseases.
SHC adaptor protein 1(SHC1)
SHC1, SHCA, SHC adaptor protein 1,SHC-transforming protein 1
SHC adaptor protein 2 (SHC2)
SCK,SHCB,SLI,Protein Sck,SHC-transforming protein B,SHC-transforming protein 2
SHC adaptor protein 3 (SHC3)
N-Shc,NSHC,RAI,SHCC,Neuronal Shc,SHC-transforming protein C,SHC-transforming protein 3
SHC adaptor protein 4 (SHC4)
RaLP,SHCD,SHC-transforming protein D,SH2 domain protein C4,SHC-transforming protein 4
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con SHC adaptor protein
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 58 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SHC1 | abx153080 | Human SHC-Transforming Protein 1 (SHC1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | SHC1 | abx494685 | Human SHC-Transforming Protein 1 (SHC1) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.117 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | SHC1 | abx595542 | SHC-Transforming Protein 1 (SHC1) Cell ELISA Kit | Human | Cell ELISA | 493.75 | 96 tests | P29353 | RUO | |||
Abbexa | SHC2 | abx545712 | Human SHC-transforming protein 2 (SHC2) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P98077 | RUO | ||
Abbexa | SHC3 | abx545715 | Human SHC-transforming protein 3 (SHC3) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q92529 | RUO | ||
Abbexa | SHC4 | abx545718 | Human SHC-transforming protein 4 (SHC4) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6S5L8 | RUO | ||
Abbexa | SHC1 | abx545710 | Mouse SHC-transforming protein 1 (SHC1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P98083 | RUO | ||
Abbexa | SHC2 | abx545713 | Mouse SHC-transforming protein 2 (SHC2) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8BMC3 | RUO | ||
Abbexa | SHC3 | abx545716 | Mouse SHC-transforming protein 3 (SHC3) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q61120 | RUO | ||
Abbexa | SHC4 | abx545719 | Mouse SHC-transforming protein 4 (SHC4) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6S5L9 | RUO | ||
Abbexa | SHC1 | abx545711 | Rat SHC-Transforming Protein 1 (SHC1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5M824 | RUO | ||
Abbexa | SHC2 | abx545714 | Rat SHC-Transforming Protein 2 (SHC2) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O70142 | RUO | ||
Abbexa | SHC3 | abx545717 | Rat SHC-Transforming Protein 3 (SHC3) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O70143 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | SHC3 | FNab07841 | anti- SHC3 antibody | human | polyclonal | Rabbit | SHC(Src homology 2 domain containing) transforming protein 3 | IgG | Unconjugated | ELISA, WB, IHC, IP | 100µg | Q92529 | RUO | |
FineTest | SHC4 | FNab07842 | anti- SHC4 antibody | human | polyclonal | Rabbit | SHC(Src homology 2 domain containing) family, member 4 | IgG | Unconjugated | ELISA, WB | 100µg | Q6S5L8 | RUO | |
Abbexa | SHC1 | abx315335 | SHC-Transforming Protein 1 (SHC1) Antibody (HRP) | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 (SHC1) | HRP | ELISA | 162.5 | 20 µg | P29353 | RUO | |
Abbexa | SHC1 | abx129003 | SHC-Transforming Protein 1 (SHC1) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 (SHC1) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P29353 | RUO | |
Abbexa | SHC1 | abx315337 | SHC-Transforming Protein 1 (SHC1) Antibody (Biotin) | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 (SHC1) | Biotin | ELISA | 162.5 | 20 µg | P29353 | RUO | |
Abbexa | SHC1 | abx302224 | SHC-Transforming Protein 1 (SHC1) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 (SHC1) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | P29353 | RUO | |
Abbexa | SHC1 | abx315336 | SHC-Transforming Protein 1 (SHC1) Antibody (FITC) | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 (SHC1) | FITC | 162.5 | 20 µg | P29353 | RUO | ||
Abbexa | SHC1 | abx174540 | SHC-Transforming Protein 1 (SHC1) Antibody | Human | Monoclonal | Mouse | SHC-Transforming Protein 1 (SHC1) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | SHC1 | abx332969 | SHC Adaptor Protein 1 Phospho-Tyr349 (SHC1 pY349) Antibody | Human | Polyclonal | Rabbit | SHC Adaptor Protein 1 Phospho-Tyr349 (SHC1 pY349) | Unconjugated | ELISA, WB, IF/ICC | 412.5 | 100 µl | P29353 | RUO | |
Abbexa | SHC1 | abx224090 | SHC-Transforming Protein 1 (SHC1) Antibody | Human | Monoclonal | Mouse | SHC-Transforming Protein 1 (SHC1) | ELISA, WB, IF/ICC, FCM | 362.5 | 100 µl | RUO | |||
Abbexa | SHC1 | abx325226 | SHC Adaptor Protein 1 Phospho-Ser36 (SHC1 pS36) Antibody | Human | Polyclonal | Rabbit | SHC Adaptor Protein 1 Phospho-Ser36 (SHC1 pS36) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | P29353 | RUO | |
Abbexa | SHC1 | abx328306 | SHC Adaptor Protein 1 Phospho-Tyr427 (SHC1 pY427) Antibody | Human | Polyclonal | Rabbit | SHC Adaptor Protein 1 Phospho-Tyr427 (SHC1 pY427) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | P29353 | RUO | |
Abbexa | SHC1 | abx123067 | SHC-Transforming Protein 1 (SHC1) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 (SHC1) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | P29353 | RUO | |
Abbexa | SHC1 | abx328552 | SHC-Transforming Protein 1 (SHC1) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 (SHC1) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | P29353 | RUO | |
Abbexa | SHC1 | abx328305 | SHC Adaptor Protein 1 Phospho-Tyr349 (SHC1 pY349) Antibody | Human | Polyclonal | Rabbit | SHC Adaptor Protein 1 Phospho-Tyr349 (SHC1 pY349) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | P29353 | RUO | |
Abbexa | SHC1 | abx012408 | SHC-Transforming Protein 1 Phospho-Tyr427 (SHC1 pY427) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 Phospho-Tyr427 (SHC1 pY427) | Unconjugated | WB, IHC | 43.75 | 10 µg | P29353 | RUO | |
Abbexa | SHC1 | abx237840 | SHC-Transforming Protein 1 (SHC1) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 (SHC1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | P29353 | RUO | |
Abbexa | SHC1 | abx329719 | SHC-Transforming Protein 1 (SHC1) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 (SHC1) | Unconjugated | ELISA, WB, IHC, IP | 187.5 | 50 µg | P29353 | RUO | |
Abbexa | SHC1 | abx012407 | SHC-Transforming Protein 1 Phospho-Tyr349 (SHC1 pY349) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 Phospho-Tyr349 (SHC1 pY349) | Unconjugated | WB, IHC | 43.75 | 10 µg | P29353 | RUO | |
Abbexa | SHC1 | abx237839 | SHC-Transforming Protein 1 (SHC1) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 (SHC1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | P29353 | RUO | |
Abbexa | SHC1 | abx115528 | SHC-Transforming Protein 1 (SHC1) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 1 (SHC1) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | P29353 | RUO | |
Abbexa | SHC1 | abx333216 | SHC Adaptor Protein 1 Phospho-Tyr427 (SHC1 pY427) Antibody | Human | Polyclonal | Rabbit | SHC Adaptor Protein 1 Phospho-Tyr427 (SHC1 pY427) | Unconjugated | ELISA, WB, IHC, IF/ICC | 412.5 | 100 µl | P29353 | RUO | |
Abbexa | SHC2 | abx330129 | SHC-Transforming Protein 2 (SHC2) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 2 (SHC2) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P98077 | RUO | |
Abbexa | SHC2 | abx015637 | SHC-Transforming Protein 2 (SHC2) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 2 (SHC2) | Unconjugated | ELISA, WB | 43.75 | 10 µg | RUO | ||
Abbexa | SHC3 | abx129117 | SHC-Transforming Protein 3 (SHC3) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 3 (SHC3) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | SHC3 | abx337675 | SHC-Transforming Protein 3 (SHC3) Antibody (Biotin) | Human | Polyclonal | Rabbit | SHC-Transforming Protein 3 (SHC3) | Biotin | ELISA | 162.5 | 20 µg | Q92529 | RUO | |
Abbexa | SHC3 | abx337673 | SHC-Transforming Protein 3 (SHC3) Antibody (HRP) | Human | Polyclonal | Rabbit | SHC-Transforming Protein 3 (SHC3) | HRP | ELISA | 162.5 | 20 µg | Q92529 | RUO | |
Abbexa | SHC3 | abx337674 | SHC-Transforming Protein 3 (SHC3) Antibody (FITC) | Human | Polyclonal | Rabbit | SHC-Transforming Protein 3 (SHC3) | FITC | 162.5 | 20 µg | Q92529 | RUO | ||
Abbexa | SHC3 | abx338781 | SHC-Transforming Protein 3 (SHC3) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 3 (SHC3) | Unconjugated | ELISA, WB | 162.5 | 20 µg | Q92529 | RUO | |
Abbexa | SHC3 | abx237841 | SHC-Transforming Protein 3 (SHC3) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 3 (SHC3) | Unconjugated | ELISA, WB, IHC, IP | 350 | 100 µg | Q92529 | RUO | |
Abbexa | SHC3 | abx115529 | SHC-Transforming Protein 3 (Shc3) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 3 (Shc3) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | Q92529 | RUO | |
Abbexa | SHC3 | abx014888 | SHC-Transforming Protein 3 (SHC3) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 3 (SHC3) | Unconjugated | IHC | 43.75 | 10 µg | Q92529 | RUO | |
Abbexa | SHC3 | abx326455 | SHC-Transforming Protein 3 (SHC3) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 3 (SHC3) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | Q92529 | RUO | |
Abbexa | SHC4 | abx320605 | SHC-Transforming Protein 4 (SHC4) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 4 (SHC4) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | Q6S5L8 | RUO | |
Abbexa | SHC4 | abx321645 | SHC-Transforming Protein 4 (SHC4) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 4 (SHC4) | Unconjugated | ELISA, WB, IHC | 237.5 | 50 µl | Q6S5L8 | RUO | |
Abbexa | SHC4 | abx237842 | SHC-Transforming Protein 4 (SHC4) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 4 (SHC4) | Unconjugated | ELISA, WB | 350 | 100 µg | Q6S5L8 | RUO | |
Abbexa | SHC4 | abx115527 | SHC-Transforming Protein 4 (SHC4) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 4 (SHC4) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q6S5L8 | RUO | |
Abbexa | SHC4 | abx005792 | SHC-Transforming Protein 4 (SHC4) Antibody | Human | Polyclonal | Rabbit | SHC-Transforming Protein 4 (SHC4) | Unconjugated | WB, IF/ICC | 175 | 20 µl | Q6S5L8 | RUO | |
Abbexa | SHC1 | abx031129 | Mouse Shc1 Antibody | Mouse | Polyclonal | Rabbit | Mouse Shc1 | Unconjugated | ELISA, WB | 281.25 | 80 µl | P98083 | RUO | |
Abbexa | SHC2 | abx102692 | SHC-Transforming Protein 2 (SHC2) Antibody | Mouse | Polyclonal | Rabbit | SHC-Transforming Protein 2 (SHC2) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | SHC4 | abx031131 | Mouse Shc4 Antibody | Mouse | Polyclonal | Rabbit | Mouse Shc4 | Unconjugated | ELISA, WB | 250 | 80 µl | Q6S5L9 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SHC1 | abx167860 | Human SHC-Transforming Protein 1 (SHC1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P29353 | RUO |
Abbexa | SHC1 | abx261464 | SHC-Transforming Protein 1 (SHC1) Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | P29353 | RUO | ||
Abbexa | SHC2 | abx069056 | Mouse SHC-Transforming Protein 2 (SHC2) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q8BMC3 | RUO |
Abbexa | SHC3 | abx165962 | Human SHC-Transforming Protein 3 (SHC3) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | RUO |
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