anti- SHC3 antibody
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935106861
info@markelab.com
Precio
Precio a consultar
Antibody anti-SHC3
proveedor
FineTestreference
FNab07841Tested Applications
ELISA, WB, IHC, IPreactivity
human,mouse,ratstatus
RUOclonality
polyclonalDescripción
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Background
SHC3, also known as N-Shc, is a neuron-specific adaptor protein involved in neurotrophin signaling and neuronal development. It shares structural similarities with SHC1 and SHC2, containing PTB and SH2 domains that mediate interactions with phosphorylated receptor tyrosine kinases, including Trk receptors. SHC3 specifically activates pathways such as Ras/MAPK, PI3K/Akt, and ERK, promoting neuronal survival, differentiation, and axonal growth. It is highly expressed in the developing and adult nervous system, where it regulates synaptic plasticity, neuronal connectivity, and brain function. Dysregulation of SHC3 has been linked to neurodevelopmental disorders, neurodegeneration, and certain brain cancers, where aberrant activation of signaling pathways affects neuronal survival and proliferation. Knockout studies reveal impaired neurotrophin signaling, reduced axonal outgrowth, and defects in synaptic connectivity, underscoring its critical role in brain development, neuronal maintenance, and signal transduction in the central nervous system.
Características del producto
category
Primary Antibodies
clonality
polyclonal
reactivity
human,mouse,rat
immunogen target
SHC(Src homology 2 domain containing) transforming protein 3
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
liquid
tested applications
ELISA, WB, IHC, IP
observerd MW
64 kDa
purity
≥95% as determined by SDS-PAGE
purification
Immunogen affinity purified
recommended dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
size 1
100µg
storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
or code
SHC3
alias
N-Shc,NSHC,RAI,SHCC,Neuronal Shc,SHC-transforming protein C,SHC-transforming protein 3
uniprot id
note
This product is for research use only.
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