SHC3 antibody
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935106861
info@markelab.com
name
SHC3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07841
tested applications
ELISA, WB, IHC, IP
Description
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SHC(Src homology 2 domain containing) transforming protein 3 (SHC3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 64 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q92529 |
| Gene ID | 53358 |
| Alias | N-Shc,NSHC,RAI,SHCC,Neuronal Shc,SHC-transforming protein C,SHC-transforming protein 3 |
| Background | Antibody anti-SHC3 |
| Status | RUO |
| Note | Mol. Weight 64 kDa |
Descripción
SHC3, also known as N-Shc, is a neuron-specific adaptor protein involved in neurotrophin signaling and neuronal development. It shares structural similarities with SHC1 and SHC2, containing PTB and SH2 domains that mediate interactions with phosphorylated receptor tyrosine kinases, including Trk receptors. SHC3 specifically activates pathways such as Ras/MAPK, PI3K/Akt, and ERK, promoting neuronal survival, differentiation, and axonal growth. It is highly expressed in the developing and adult nervous system, where it regulates synaptic plasticity, neuronal connectivity, and brain function. Dysregulation of SHC3 has been linked to neurodevelopmental disorders, neurodegeneration, and certain brain cancers, where aberrant activation of signaling pathways affects neuronal survival and proliferation. Knockout studies reveal impaired neurotrophin signaling, reduced axonal outgrowth, and defects in synaptic connectivity, underscoring its critical role in brain development, neuronal maintenance, and signal transduction in the central nervous system.
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