Human SHC-Transforming Protein 1 (SHC1) Protein
221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human SHC-Transforming Protein 1 (SHC1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167860
tested applications
WB, SDS-PAGE
Description
SHC-Transforming Protein 1 is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | SHC-Transforming Protein 1 (SHC1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 35.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu272-His559 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29353 |
| Alias | SHC1, SHCA, SHC adaptor protein 1,SHC-transforming protein 1 |
| Background | Protein SHC1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SHC1 is an adaptor protein that plays a critical role in linking receptor tyrosine kinases (RTKs) and cytokine receptors to downstream signaling pathways such as Ras/MAPK, PI3K/Akt, and JNK. It contains PTB and SH2 domains that mediate interactions with phosphorylated tyrosine residues on activated receptors, facilitating the recruitment of Grb2 and SOS to activate Ras signaling. SHC1 is widely expressed and is involved in cellular processes such as proliferation, survival, differentiation, and stress responses. It exists in multiple isoforms, including p46, p52, and p66, with p66 SHC1 acting as a redox sensor that regulates oxidative stress and apoptosis. Dysregulation of SHC1 contributes to cancer progression, as it enhances cell survival and proliferation through oncogenic signaling pathways, and has also been linked to aging and cardiovascular diseases. Knockout studies reveal defects in growth factor signaling, increased oxidative stress resistance, and reduced tumorigenesis, underscoring its dual role in promoting survival signaling and regulating cellular stress responses.
