Human SHC-Transforming Protein 3 (SHC3) Protein
221€ (10 µg)
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935106861
info@markelab.com
name
Human SHC-Transforming Protein 3 (SHC3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx165962
tested applications
WB, SDS-PAGE
Description
SHC-Transforming Protein 3 is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | SHC-Transforming Protein 3 (SHC3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 57.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val188-Gln433 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | N-Shc,NSHC,RAI,SHCC,Neuronal Shc,SHC-transforming protein C,SHC-transforming protein 3 |
| Background | Protein SHC3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SHC3, also known as N-Shc, is a neuron-specific adaptor protein involved in neurotrophin signaling and neuronal development. It shares structural similarities with SHC1 and SHC2, containing PTB and SH2 domains that mediate interactions with phosphorylated receptor tyrosine kinases, including Trk receptors. SHC3 specifically activates pathways such as Ras/MAPK, PI3K/Akt, and ERK, promoting neuronal survival, differentiation, and axonal growth. It is highly expressed in the developing and adult nervous system, where it regulates synaptic plasticity, neuronal connectivity, and brain function. Dysregulation of SHC3 has been linked to neurodevelopmental disorders, neurodegeneration, and certain brain cancers, where aberrant activation of signaling pathways affects neuronal survival and proliferation. Knockout studies reveal impaired neurotrophin signaling, reduced axonal outgrowth, and defects in synaptic connectivity, underscoring its critical role in brain development, neuronal maintenance, and signal transduction in the central nervous system.
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