SHC-Transforming Protein 4 (SHC4) Antibody

Background

SHC4, also known as RaLP (SHC-related adaptor protein-like protein), is a member of the SHC family of adaptor proteins involved in receptor tyrosine kinase (RTK) signaling. It contains the PTB and SH2 domains that mediate interactions with phosphorylated receptors and downstream signaling intermediates, activating pathways such as Ras/MAPK and PI3K/Akt to regulate processes like cell proliferation, survival, and differentiation. SHC4 is primarily expressed in neural tissues and certain cancers, where it plays an important role in neuronal development, axon guidance, and survival signaling. Dysregulation or overexpression of SHC4 is associated with tumorigenesis, particularly in melanoma and glioblastoma, where it promotes cellular proliferation, migration, and resistance to apoptosis. Knockdown studies reveal impaired cell growth, disrupted signaling pathways, and reduced tumorigenic potential, highlighting its critical function in mediating oncogenic and neuronal signaling pathways.