SHC4 antibody
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935106861
info@markelab.com
name
SHC4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07842
tested applications
ELISA, WB
Description
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SHC(Src homology 2 domain containing) family, member 4 (SHC4) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 69 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6S5L8 |
| Gene ID | 399694 |
| Alias | RaLP,SHCD,SHC-transforming protein D,SH2 domain protein C4,SHC-transforming protein 4 |
| Background | Antibody anti-SHC4 |
| Status | RUO |
| Note | Mol. Weight 69 kDa |
Descripción
SHC4, also known as RaLP (SHC-related adaptor protein-like protein), is a member of the SHC family of adaptor proteins involved in receptor tyrosine kinase (RTK) signaling. It contains the PTB and SH2 domains that mediate interactions with phosphorylated receptors and downstream signaling intermediates, activating pathways such as Ras/MAPK and PI3K/Akt to regulate processes like cell proliferation, survival, and differentiation. SHC4 is primarily expressed in neural tissues and certain cancers, where it plays an important role in neuronal development, axon guidance, and survival signaling. Dysregulation or overexpression of SHC4 is associated with tumorigenesis, particularly in melanoma and glioblastoma, where it promotes cellular proliferation, migration, and resistance to apoptosis. Knockdown studies reveal impaired cell growth, disrupted signaling pathways, and reduced tumorigenic potential, highlighting its critical function in mediating oncogenic and neuronal signaling pathways.
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