SHC-Transforming Protein 1 (SHC1) Antibody

Este producto es parte de SHC adaptor protein
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169€ (20 µg)

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935106861
info@markelab.com
name
SHC-Transforming Protein 1 (SHC1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx302224
tested applications
ELISA, IHC, IF/ICC

Description

SHC1 Antibody is a Rabbit Polyclonal against SHC1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
SHC-Transforming Protein 1 (SHC1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P29353
Gene ID
6464
NCBI Accession
NM_183001.4
OMIM
600560
Alias
SHC1, SHCA, SHC adaptor protein 1,SHC-transforming protein 1
Background
Antibody anti-SHC1
Status
RUO

Descripción

SHC1 is an adaptor protein that plays a critical role in linking receptor tyrosine kinases (RTKs) and cytokine receptors to downstream signaling pathways such as Ras/MAPK, PI3K/Akt, and JNK. It contains PTB and SH2 domains that mediate interactions with phosphorylated tyrosine residues on activated receptors, facilitating the recruitment of Grb2 and SOS to activate Ras signaling. SHC1 is widely expressed and is involved in cellular processes such as proliferation, survival, differentiation, and stress responses. It exists in multiple isoforms, including p46, p52, and p66, with p66 SHC1 acting as a redox sensor that regulates oxidative stress and apoptosis. Dysregulation of SHC1 contributes to cancer progression, as it enhances cell survival and proliferation through oncogenic signaling pathways, and has also been linked to aging and cardiovascular diseases. Knockout studies reveal defects in growth factor signaling, increased oxidative stress resistance, and reduced tumorigenesis, underscoring its dual role in promoting survival signaling and regulating cellular stress responses.

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