SHC-Transforming Protein 1 (SHC1) Antibody
169€ (20 µg)
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935106861
info@markelab.com
name
SHC-Transforming Protein 1 (SHC1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx302224
tested applications
ELISA, IHC, IF/ICC
Description
SHC1 Antibody is a Rabbit Polyclonal against SHC1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SHC-Transforming Protein 1 (SHC1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29353 |
| Gene ID | 6464 |
| NCBI Accession | NM_183001.4 |
| OMIM | 600560 |
| Alias | SHC1, SHCA, SHC adaptor protein 1,SHC-transforming protein 1 |
| Background | Antibody anti-SHC1 |
| Status | RUO |
Descripción
SHC1 is an adaptor protein that plays a critical role in linking receptor tyrosine kinases (RTKs) and cytokine receptors to downstream signaling pathways such as Ras/MAPK, PI3K/Akt, and JNK. It contains PTB and SH2 domains that mediate interactions with phosphorylated tyrosine residues on activated receptors, facilitating the recruitment of Grb2 and SOS to activate Ras signaling. SHC1 is widely expressed and is involved in cellular processes such as proliferation, survival, differentiation, and stress responses. It exists in multiple isoforms, including p46, p52, and p66, with p66 SHC1 acting as a redox sensor that regulates oxidative stress and apoptosis. Dysregulation of SHC1 contributes to cancer progression, as it enhances cell survival and proliferation through oncogenic signaling pathways, and has also been linked to aging and cardiovascular diseases. Knockout studies reveal defects in growth factor signaling, increased oxidative stress resistance, and reduced tumorigenesis, underscoring its dual role in promoting survival signaling and regulating cellular stress responses.
