Human SHC-transforming protein 2 (SHC2) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for SHC2
proveedor
Abbexareference
abx545712Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human SHC-transforming protein 2 (SHC2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SHC-transforming protein 2 (SHC2) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Background
SHC2, also known as SCK, is an adaptor protein primarily expressed in neural tissues, where it mediates signaling downstream of receptor tyrosine kinases and neurotrophin receptors, including TrkA/B. Like SHC1, it contains PTB and SH2 domains that facilitate interactions with phosphorylated receptors, activating Ras/MAPK and PI3K/Akt pathways to regulate processes such as neuronal survival, differentiation, and synaptic plasticity. SHC2 is essential for neurotrophin signaling, supporting neural development and maintenance of neuronal connections in the brain. Dysregulation of SHC2 has been associated with neurodevelopmental and neurodegenerative disorders, including impaired neuronal survival and axon guidance. Studies suggest that altered SHC2 expression may also contribute to certain cancers through its ability to regulate mitogenic and survival signaling pathways. Knockout models display defects in neuronal signaling, synapse formation, and brain development, highlighting its specialized role in the nervous system and neurotrophin-mediated signaling pathways.
Características del producto
category
ELISA Kits
immunogen target
SHC-transforming protein 2 (SHC2)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
size 1
96 tests
alias
SCK,SHCB,SLI,Protein Sck,SHC-transforming protein B,SHC-transforming protein 2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SHC2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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