Rat SHC-Transforming Protein 3 (SHC3) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for SHC3
proveedor
Abbexareference
abx545717Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat SHC-Transforming Protein 3 (SHC3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat SHC-transforming protein 3 concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Background
SHC3, also known as N-Shc, is a neuron-specific adaptor protein involved in neurotrophin signaling and neuronal development. It shares structural similarities with SHC1 and SHC2, containing PTB and SH2 domains that mediate interactions with phosphorylated receptor tyrosine kinases, including Trk receptors. SHC3 specifically activates pathways such as Ras/MAPK, PI3K/Akt, and ERK, promoting neuronal survival, differentiation, and axonal growth. It is highly expressed in the developing and adult nervous system, where it regulates synaptic plasticity, neuronal connectivity, and brain function. Dysregulation of SHC3 has been linked to neurodevelopmental disorders, neurodegeneration, and certain brain cancers, where aberrant activation of signaling pathways affects neuronal survival and proliferation. Knockout studies reveal impaired neurotrophin signaling, reduced axonal outgrowth, and defects in synaptic connectivity, underscoring its critical role in brain development, neuronal maintenance, and signal transduction in the central nervous system.
Características del producto
category
ELISA Kits
immunogen target
SHC-Transforming Protein 3 (SHC3)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
size 1
96 tests
alias
N-Shc,NSHC,RAI,SHCC,Neuronal Shc,SHC-transforming protein C,SHC-transforming protein 3
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SHC3
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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