SHC-Transforming Protein 1 Phospho-Tyr349 (SHC1 pY349) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
SHC-Transforming Protein 1 Phospho-Tyr349 (SHC1 pY349) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012407
tested applications
ELISA, WB, IHC
Description
Rabbit polyclonal antibody against Shc protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:Y349, M:Y349, R:Y349.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SHC-Transforming Protein 1 Phospho-Tyr349 (SHC1 pY349) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr349 |
| Recommended Dilution | WB: 1/500 - 3000, IHC: 1/50 - 100, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29353 |
| Alias | SHC1, SHCA, SHC adaptor protein 1,SHC-transforming protein 1 |
| Background | Antibody anti-SHC1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
SHC1 is an adaptor protein that plays a critical role in linking receptor tyrosine kinases (RTKs) and cytokine receptors to downstream signaling pathways such as Ras/MAPK, PI3K/Akt, and JNK. It contains PTB and SH2 domains that mediate interactions with phosphorylated tyrosine residues on activated receptors, facilitating the recruitment of Grb2 and SOS to activate Ras signaling. SHC1 is widely expressed and is involved in cellular processes such as proliferation, survival, differentiation, and stress responses. It exists in multiple isoforms, including p46, p52, and p66, with p66 SHC1 acting as a redox sensor that regulates oxidative stress and apoptosis. Dysregulation of SHC1 contributes to cancer progression, as it enhances cell survival and proliferation through oncogenic signaling pathways, and has also been linked to aging and cardiovascular diseases. Knockout studies reveal defects in growth factor signaling, increased oxidative stress resistance, and reduced tumorigenesis, underscoring its dual role in promoting survival signaling and regulating cellular stress responses.
