SHC-Transforming Protein 2 (SHC2) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
SHC-Transforming Protein 2 (SHC2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015637
tested applications
WB
Description
Rabbit Polyclonal to SHC2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SHC-Transforming Protein 2 (SHC2) |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | Please contact us for details. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | SCK,SHCB,SLI,Protein Sck,SHC-transforming protein B,SHC-transforming protein 2 |
| Background | Antibody anti-SHC2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
SHC2, also known as SCK, is an adaptor protein primarily expressed in neural tissues, where it mediates signaling downstream of receptor tyrosine kinases and neurotrophin receptors, including TrkA/B. Like SHC1, it contains PTB and SH2 domains that facilitate interactions with phosphorylated receptors, activating Ras/MAPK and PI3K/Akt pathways to regulate processes such as neuronal survival, differentiation, and synaptic plasticity. SHC2 is essential for neurotrophin signaling, supporting neural development and maintenance of neuronal connections in the brain. Dysregulation of SHC2 has been associated with neurodevelopmental and neurodegenerative disorders, including impaired neuronal survival and axon guidance. Studies suggest that altered SHC2 expression may also contribute to certain cancers through its ability to regulate mitogenic and survival signaling pathways. Knockout models display defects in neuronal signaling, synapse formation, and brain development, highlighting its specialized role in the nervous system and neurotrophin-mediated signaling pathways.
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