Mouse SHC-Transforming Protein 2 (SHC2) Protein
234€ (10 µg)
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935106861
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name
Mouse SHC-Transforming Protein 2 (SHC2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069056
tested applications
WB, SDS-PAGE
Description
Recombinant SHC-Transforming Protein 2 (SHC2) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | SHC-Transforming Protein 2 (SHC2) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 26.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp98-Glu302 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8BMC3 |
| Alias | SCK,SHCB,SLI,Protein Sck,SHC-transforming protein B,SHC-transforming protein 2 |
| Background | Protein SHC2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SHC2, also known as SCK, is an adaptor protein primarily expressed in neural tissues, where it mediates signaling downstream of receptor tyrosine kinases and neurotrophin receptors, including TrkA/B. Like SHC1, it contains PTB and SH2 domains that facilitate interactions with phosphorylated receptors, activating Ras/MAPK and PI3K/Akt pathways to regulate processes such as neuronal survival, differentiation, and synaptic plasticity. SHC2 is essential for neurotrophin signaling, supporting neural development and maintenance of neuronal connections in the brain. Dysregulation of SHC2 has been associated with neurodevelopmental and neurodegenerative disorders, including impaired neuronal survival and axon guidance. Studies suggest that altered SHC2 expression may also contribute to certain cancers through its ability to regulate mitogenic and survival signaling pathways. Knockout models display defects in neuronal signaling, synapse formation, and brain development, highlighting its specialized role in the nervous system and neurotrophin-mediated signaling pathways.
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