Mouse SHC-transforming protein 4 (SHC4) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for SHC4
proveedor
Abbexareference
abx545719Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse SHC-transforming protein 4 (SHC4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse SHC-transforming protein 4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
SHC4, also known as RaLP (SHC-related adaptor protein-like protein), is a member of the SHC family of adaptor proteins involved in receptor tyrosine kinase (RTK) signaling. It contains the PTB and SH2 domains that mediate interactions with phosphorylated receptors and downstream signaling intermediates, activating pathways such as Ras/MAPK and PI3K/Akt to regulate processes like cell proliferation, survival, and differentiation. SHC4 is primarily expressed in neural tissues and certain cancers, where it plays an important role in neuronal development, axon guidance, and survival signaling. Dysregulation or overexpression of SHC4 is associated with tumorigenesis, particularly in melanoma and glioblastoma, where it promotes cellular proliferation, migration, and resistance to apoptosis. Knockdown studies reveal impaired cell growth, disrupted signaling pathways, and reduced tumorigenic potential, highlighting its critical function in mediating oncogenic and neuronal signaling pathways.
Características del producto
category
ELISA Kits
immunogen target
SHC-transforming protein 4 (SHC4)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
RaLP,SHCD,SHC-transforming protein D,SH2 domain protein C4,SHC-transforming protein 4
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SHC4
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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