Mouse SHC-transforming protein 4 (SHC4) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse SHC-transforming protein 4 (SHC4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx545719
tested applications
ELISA
Description
Mouse SHC-transforming protein 4 (SHC4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse SHC-transforming protein 4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | SHC-transforming protein 4 (SHC4) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q6S5L9 |
| Gene ID | 271849 |
| Alias | RaLP,SHCD,SHC-transforming protein D,SH2 domain protein C4,SHC-transforming protein 4 |
| Background | Elisa kits for SHC4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SHC4, also known as RaLP (SHC-related adaptor protein-like protein), is a member of the SHC family of adaptor proteins involved in receptor tyrosine kinase (RTK) signaling. It contains the PTB and SH2 domains that mediate interactions with phosphorylated receptors and downstream signaling intermediates, activating pathways such as Ras/MAPK and PI3K/Akt to regulate processes like cell proliferation, survival, and differentiation. SHC4 is primarily expressed in neural tissues and certain cancers, where it plays an important role in neuronal development, axon guidance, and survival signaling. Dysregulation or overexpression of SHC4 is associated with tumorigenesis, particularly in melanoma and glioblastoma, where it promotes cellular proliferation, migration, and resistance to apoptosis. Knockdown studies reveal impaired cell growth, disrupted signaling pathways, and reduced tumorigenic potential, highlighting its critical function in mediating oncogenic and neuronal signaling pathways.
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