SHC-Transforming Protein 1 (SHC1) Antibody
819€ (1 ml)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
SHC-Transforming Protein 1 (SHC1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx174540
tested applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SHC-Transforming Protein 1 (SHC1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | SHC1, SHCA, SHC adaptor protein 1,SHC-transforming protein 1 |
| Background | Antibody anti-SHC1 |
| Status | RUO |
Descripción
SHC1 is an adaptor protein that plays a critical role in linking receptor tyrosine kinases (RTKs) and cytokine receptors to downstream signaling pathways such as Ras/MAPK, PI3K/Akt, and JNK. It contains PTB and SH2 domains that mediate interactions with phosphorylated tyrosine residues on activated receptors, facilitating the recruitment of Grb2 and SOS to activate Ras signaling. SHC1 is widely expressed and is involved in cellular processes such as proliferation, survival, differentiation, and stress responses. It exists in multiple isoforms, including p46, p52, and p66, with p66 SHC1 acting as a redox sensor that regulates oxidative stress and apoptosis. Dysregulation of SHC1 contributes to cancer progression, as it enhances cell survival and proliferation through oncogenic signaling pathways, and has also been linked to aging and cardiovascular diseases. Knockout studies reveal defects in growth factor signaling, increased oxidative stress resistance, and reduced tumorigenesis, underscoring its dual role in promoting survival signaling and regulating cellular stress responses.
