Family main features
Receptor Activity Modifying Proteins (RAMPs) are not themselves G protein-coupled receptors (GPCRs), but they are closely associated with GPCRs and play a crucial role in modulating their activity. Here's an overview of RAMPs:
RAMPs are small single-pass transmembrane proteins that interact with certain GPCRs to modify their pharmacological properties, trafficking, and signaling pathways. They are comprised of three subtypes: RAMP1, RAMP2, and RAMP3.
RAMPs associate with specific GPCRs to form functional receptor complexes. For example, RAMP1 interacts with the calcitonin receptor-like receptor (CLR) to form the calcitonin gene-related peptide (CGRP) receptor, while RAMP2 and RAMP3 associate with CLR to form the adrenomedullin (AM) receptor.
By forming complexes with GPCRs, RAMPs can significantly alter the pharmacological properties and signaling pathways of these receptors. They can influence ligand binding affinity, receptor trafficking to the cell surface, downstream signaling cascades, and receptor desensitization and internalization.
RAMP-associated receptors play essential roles in various physiological processes, including cardiovascular regulation, vasodilation, pain modulation, and metabolism. For example, the CGRP receptor, composed of RAMP1 and CLR, is involved in vasodilation and pain transmission, while the AM receptor, composed of RAMP2/3 and CLR, regulates vascular tone and blood pressure.
Dysregulation of RAMP-associated receptors has been implicated in several pathological conditions, including migraine, hypertension, cardiovascular diseases, and metabolic disorders. Modulation of RAMP-associated receptor activity represents a potential therapeutic target for the treatment of these conditions.
Targeting RAMP-associated receptors with pharmacological agents that modulate their activity holds promise for the development of novel
Receptor Activity Modifying Protein 1 (RAMP1)
RAMP1,CTR
Receptor Activity Modifying Protein 2 (RAMP2)
RAMP2
Receptor Activity Modifying Protein 3 (RAMP3)
Receptor Activity Modifying Protein 3 (RAMP3)
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con RAMP - Receptor Activity Modifying Protein
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 40 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | RAMP1 | EH4204 | Human RAMP1(Receptor activity-modifying protein 1) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | O60894 | RUO | ||
Abbexa | RAMP1 | abx257520 | Human Receptor Activity Modifying Protein 1 (RAMP1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O60894 | RUO | ||
Abbexa | RAMP2 | abx495414 | Human Receptor Activity Modifying Protein 2 (RAMP2) CLIA Kit | Human | Tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.059 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | RAMP2 | abx152920 | Human Receptor Activity Modifying Protein 2 (RAMP2) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | RAMP3 | abx382675 | Human Receptor Activity Modifying Protein 3 (RAMP3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.188 ng/ml | 687.5 | 96 tests | O60896 | RUO |
Abbexa | RAMP1 | abx541353 | Mouse Receptor Activity Modifying Protein 1 (RAMP1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9WTJ5 | RUO | ||
Abbexa | RAMP2 | abx541357 | Mouse Receptor activity-modifying protein 2 (RAMP2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9WUP0 | RUO | ||
Abbexa | RAMP3 | abx541360 | Mouse Receptor activity-modifying protein 3 (RAMP3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9WUP1 | RUO | ||
Abbexa | RAMP1 | abx541355 | Rat Receptor Activity Modifying Protein 1 (RAMP1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9JJ74 | RUO | ||
Abbexa | RAMP2 | abx541358 | Rat Receptor Activity Modifying Protein 2 (RAMP2) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9JHJ1 | RUO | ||
Abbexa | RAMP3 | abx541362 | Rat Receptor Activity Modifying Protein 3 (RAMP3) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9JJ73 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | RAMP1 | FNab07097 | anti- RAMP1 antibody | human | polyclonal | Rabbit | receptor(G protein-coupled) activity modifying protein 1 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | O60894 | RUO | |
FineTest | RAMP2 | FNab07098 | anti- RAMP2 antibody | human | polyclonal | Rabbit | receptor(G protein-coupled) activity modifying protein 2 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | O60895 | RUO | |
FineTest | RAMP3 | FNab07099 | anti- RAMP3 antibody | human | polyclonal | Rabbit | receptor(G protein-coupled) activity modifying protein 3 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | O60896 | RUO | |
Abbexa | RAMP1 | abx115081 | Receptor Activity Modifying Protein 1 (RAMP1) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 1 (RAMP1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | O60894 | RUO | |
Abbexa | RAMP1 | abx211682 | Receptor Activity Modifying Protein 1 (RAMP1) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 1 (RAMP1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O60894 | RUO | |
Abbexa | RAMP1 | abx237097 | Receptor Activity Modifying Protein 1 (RAMP1) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 1 (RAMP1) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | O60894 | RUO | |
Abbexa | RAMP1 | abx004940 | Receptor Activity Modifying Protein 1 (RAMP1) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 1 (RAMP1) | Unconjugated | WB, IF/ICC | 175 | 20 µl | O60894 | RUO | |
Abbexa | RAMP2 | abx339999 | Receptor Activity Modifying Protein 2 (RAMP2) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 2 (RAMP2) | Unconjugated | ELISA, WB | 250 | 50 µl | O60895 | RUO | |
Abbexa | RAMP2 | abx174342 | Receptor Activity Modifying Protein 2 (RAMP2) Antibody | Human | Monoclonal | Mouse | Receptor Activity Modifying Protein 2 (RAMP2) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | RAMP2 | abx178218 | Receptor Activity Modifying Protein 2 (RAMP2) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 2 (RAMP2) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | RAMP2 | abx337445 | Receptor Activity Modifying Protein 2 (RAMP2) Antibody (FITC) | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 2 (RAMP2) | FITC | 162.5 | 20 µg | O60895 | RUO | ||
Abbexa | RAMP2 | abx334220 | Receptor Activity Modifying Protein 2 (RAMP2) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 2 (RAMP2) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | O60895 | RUO | |
Abbexa | RAMP2 | abx337446 | Receptor Activity Modifying Protein 2 (RAMP2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 2 (RAMP2) | Biotin | ELISA | 162.5 | 20 µg | O60895 | RUO | |
Abbexa | RAMP2 | abx337444 | Receptor Activity Modifying Protein 2 (RAMP2) Antibody (HRP) | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 2 (RAMP2) | HRP | ELISA | 162.5 | 20 µg | O60895 | RUO | |
Abbexa | RAMP2 | abx376268 | Receptor Activity Modifying Protein 2 (RAMP2) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 2 (RAMP2) | Unconjugated | ELISA, WB | 337.5 | 100 µg | O60895 | RUO | |
Abbexa | RAMP2 | abx002216 | Receptor Activity Modifying Protein 2 (RAMP2) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 2 (RAMP2) | Unconjugated | WB, IHC | 175 | 20 µl | O60895 | RUO | |
Abbexa | RAMP2 | abx237098 | Receptor Activity Modifying Protein 2 (RAMP2) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 2 (RAMP2) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | O60895 | RUO | |
Abbexa | RAMP2 | abx115082 | Receptor Activity Modifying Protein 2 (RAMP2) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 2 (RAMP2) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | O60895 | RUO | |
Abbexa | RAMP3 | abx376269 | Receptor Activity Modifying Protein 3 (RAMP3) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 3 (RAMP3) | Unconjugated | ELISA, WB | 337.5 | 100 µg | O60896 | RUO | |
Abbexa | RAMP3 | abx237099 | Receptor Activity Modifying Protein 3 (RAMP3) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 3 (RAMP3) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | O60896 | RUO | |
Abbexa | RAMP3 | abx241602 | Receptor Activity Modifying Protein 3 (RAMP3) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 3 (RAMP3) | Unconjugated | ELISA, IHC | 250 | 50 µl | O60896 | RUO | |
Abbexa | RAMP3 | abx115083 | Receptor Activity Modifying Protein 3 (RAMP3) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 3 (RAMP3) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | O60896 | RUO | |
Abbexa | RAMP3 | abx005152 | Receptor Activity Modifying Protein 3 (RAMP3) Antibody | Human | Polyclonal | Rabbit | Receptor Activity Modifying Protein 3 (RAMP3) | Unconjugated | WB, IF/ICC | 175 | 20 µl | O60896 | RUO | |
Abbexa | RAMP1 | abx431959 | Receptor Activity Modifying Protein 1 (Ramp1) Antibody | Rat | Polyclonal | Goat | Receptor Activity Modifying Protein 1 (Ramp1) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | RAMP1 | abx262736 | Receptor Activity-Modifying Protein 1 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | O60894 | RUO | ||
Abbexa | RAMP2 | abx654910 | Human Receptor Activity Modifying Protein 2 (RAMP2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 262.5 | 10 µg | RUO | |
Abbexa | RAMP3 | abx263336 | Receptor Activity-Modifying Protein 3 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | O60896 | RUO | ||
FineTest | RAMP3 | P4221 | Recombinant Human RAMP3 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | O60896 | RUO | ||
Abbexa | RAMP3 | abx690860 | Human Receptor Activity Modifying Protein 3 (RAMP3) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | RUO |
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