Human Receptor Activity Modifying Protein 1 (RAMP1) ELISA Kit
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Description
Human Receptor Activity Modifying Protein 1 (RAMP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human RAMP1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Receptor Activity Modifying Protein 1 (RAMP1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O60894 |
| Alias | RAMP1,CTR |
| Background | Elisa kits for RAMP1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Receptor Activity Modifying Protein 1 (RAMP1) is a member of the RAMP family that plays a crucial role in modulating the activity and function of G-protein-coupled receptors (GPCRs), particularly the calcitonin receptor-like receptor (CRLR). RAMP1 specifically partners with CRLR to form the calcitonin gene-related peptide (CGRP) receptor, which is involved in diverse physiological processes, including vasodilation, pain modulation, and neurogenic inflammation. CGRP signaling, facilitated by RAMP1, is critical for maintaining vascular homeostasis by relaxing vascular smooth muscle cells and increasing blood flow. This pathway also contributes to migraine pathophysiology, where elevated CGRP levels and RAMP1 expression have been linked to migraine attacks. RAMP1 is expressed in vascular endothelial cells, sensory neurons, and tissues like the heart, lungs, and brain, underscoring its systemic relevance. Beyond vasodilation, RAMP1-CGRP signaling protects against ischemic injuries and contributes to cardioprotection during cardiac stress. Additionally, RAMP1 modulates the activity of other receptors, such as the adrenomedullin receptor, influencing fluid homeostasis and immune regulation. Targeting RAMP1 for therapeutic intervention, particularly through antagonists, has shown promise for treating migraines, hypertension, and inflammatory disorders.
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