Receptor Activity Modifying Protein 3 (RAMP3) Antibody
637€ (100 µl)
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Name
Receptor Activity Modifying Protein 3 (RAMP3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx115083
Tested Applications
ELISA, WB, IHC
Description
Receptor (G Protein-Coupled) Activity Modifying Protein 3 Antibody is a Rabbit Polyclonal antibody against Receptor (G Protein-Coupled) Activity Modifying Protein 3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Receptor Activity Modifying Protein 3 (RAMP3) Immunogen: Human RAMP3. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60896 |
| Gene ID | 10268 |
| OMIM | 605155 |
| Alias | RAMP3 |
| Background | Antibody anti-RAMP3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Receptor Activity Modifying Protein 3 (RAMP3) is a key protein that interacts with GPCRs, particularly the calcitonin receptor-like receptor (CRLR), to form the adrenomedullin 2/intermedin receptor. RAMP3 is widely expressed in tissues like the heart, kidneys, lungs, and endothelial cells, where it regulates cardiovascular homeostasis, fluid balance, and angiogenesis. By facilitating the interaction between CRLR and adrenomedullin 2, RAMP3 promotes vasodilation, anti-inflammatory effects, and cardioprotective mechanisms. RAMP3 signaling plays a significant role in protecting against cardiac hypertrophy, heart failure, and ischemic injuries by enhancing vascular remodeling and reducing oxidative stress. Furthermore, RAMP3 is involved in bone metabolism and calcium homeostasis through its modulation of calcitonin receptor signaling. Recent studies highlight its role in cancer biology, where RAMP3-mediated signaling can support tumor angiogenesis and metastasis in certain cancers. RAMP3 also participates in the regulation of G-protein signaling and receptor trafficking, influencing receptor localization and activity at the cell membrane. Targeting RAMP3 pathways has shown therapeutic potential for managing cardiovascular diseases, cancer progression, and conditions requiring vascular repair, offering promising directions for clinical research and drug development.
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