anti- RAMP2 antibody
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Description
Transports the calcitonin gene-related peptide type 1 receptor(CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin(AM) together with CALCRL.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | receptor(G protein-coupled) activity modifying protein 2 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 20 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O60895 |
| Gene ID | 10266 |
| Alias | RAMP2 |
| Background | Antibody anti-RAMP2 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Receptor Activity Modifying Protein 2 (RAMP2) is another member of the RAMP family that regulates the activity of GPCRs by interacting with the calcitonin receptor-like receptor (CRLR) to form the adrenomedullin (AM) receptor. Adrenomedullin, a potent vasodilatory peptide, plays a key role in vascular biology, angiogenesis, and fluid balance. RAMP2-AM receptor signaling is crucial for maintaining endothelial integrity, promoting vascular smooth muscle relaxation, and enhancing nitric oxide production to regulate blood pressure. RAMP2 is highly expressed in endothelial cells, cardiac tissues, and the renal system, where it contributes to fluid balance, renal function, and cardiovascular homeostasis. Its role in angiogenesis makes it essential for fetal development and tissue repair. Dysregulation of RAMP2 signaling has been implicated in diseases such as preeclampsia, pulmonary hypertension, and chronic heart failure, where impaired vascular function exacerbates pathological conditions. RAMP2 also exerts protective effects during inflammatory processes by reducing endothelial damage and promoting immune cell recruitment. Therapeutic modulation of RAMP2 function has potential applications in vascular diseases, hypertension, and conditions requiring enhanced angiogenic responses, such as wound healing or ischemic injuries.
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