RAMP1 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
RAMP1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07097
tested applications
ELISA, WB, IHC
Description
Transports the calcitonin gene-related peptide type 1 receptor(CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide(CGRP) together with CALCRL.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | receptor(G protein-coupled) activity modifying protein 1 (RAMP1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 17 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O60894 |
| Gene ID | 10267 |
| Alias | RAMP1,CTR |
| Background | Antibody anti-RAMP1 |
| Status | RUO |
| Note | Mol. Weight 17 kDa |
Descripción
Receptor Activity Modifying Protein 1 (RAMP1) is a member of the RAMP family that plays a crucial role in modulating the activity and function of G-protein-coupled receptors (GPCRs), particularly the calcitonin receptor-like receptor (CRLR). RAMP1 specifically partners with CRLR to form the calcitonin gene-related peptide (CGRP) receptor, which is involved in diverse physiological processes, including vasodilation, pain modulation, and neurogenic inflammation. CGRP signaling, facilitated by RAMP1, is critical for maintaining vascular homeostasis by relaxing vascular smooth muscle cells and increasing blood flow. This pathway also contributes to migraine pathophysiology, where elevated CGRP levels and RAMP1 expression have been linked to migraine attacks. RAMP1 is expressed in vascular endothelial cells, sensory neurons, and tissues like the heart, lungs, and brain, underscoring its systemic relevance. Beyond vasodilation, RAMP1-CGRP signaling protects against ischemic injuries and contributes to cardioprotection during cardiac stress. Additionally, RAMP1 modulates the activity of other receptors, such as the adrenomedullin receptor, influencing fluid homeostasis and immune regulation. Targeting RAMP1 for therapeutic intervention, particularly through antagonists, has shown promise for treating migraines, hypertension, and inflammatory disorders.
Related Products
Human RAMP1 (Receptor activity-modifying protein 1) ELISA Kit
Ver Producto
RAMP1 antibody
Transports the calcitonin gene-related peptide type 1 receptor(CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide(CGRP) together with CALCRL.
Ver Producto