Receptor Activity-Modifying Protein 3 Protein

Background

Receptor Activity Modifying Protein 3 (RAMP3) is a key protein that interacts with GPCRs, particularly the calcitonin receptor-like receptor (CRLR), to form the adrenomedullin 2/intermedin receptor. RAMP3 is widely expressed in tissues like the heart, kidneys, lungs, and endothelial cells, where it regulates cardiovascular homeostasis, fluid balance, and angiogenesis. By facilitating the interaction between CRLR and adrenomedullin 2, RAMP3 promotes vasodilation, anti-inflammatory effects, and cardioprotective mechanisms. RAMP3 signaling plays a significant role in protecting against cardiac hypertrophy, heart failure, and ischemic injuries by enhancing vascular remodeling and reducing oxidative stress. Furthermore, RAMP3 is involved in bone metabolism and calcium homeostasis through its modulation of calcitonin receptor signaling. Recent studies highlight its role in cancer biology, where RAMP3-mediated signaling can support tumor angiogenesis and metastasis in certain cancers. RAMP3 also participates in the regulation of G-protein signaling and receptor trafficking, influencing receptor localization and activity at the cell membrane. Targeting RAMP3 pathways has shown therapeutic potential for managing cardiovascular diseases, cancer progression, and conditions requiring vascular repair, offering promising directions for clinical research and drug development.