Human Receptor Activity Modifying Protein 2 (RAMP2) Protein
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Description
Human Receptor Activity Modifying Protein 2 (RAMP2) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Receptor Activity Modifying Protein 2 (RAMP2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 41.8 kDa Observed MW (SDS-PAGE): 43 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln43-Val145 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | RAMP2 |
| Background | Protein RAMP2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Receptor Activity Modifying Protein 2 (RAMP2) is another member of the RAMP family that regulates the activity of GPCRs by interacting with the calcitonin receptor-like receptor (CRLR) to form the adrenomedullin (AM) receptor. Adrenomedullin, a potent vasodilatory peptide, plays a key role in vascular biology, angiogenesis, and fluid balance. RAMP2-AM receptor signaling is crucial for maintaining endothelial integrity, promoting vascular smooth muscle relaxation, and enhancing nitric oxide production to regulate blood pressure. RAMP2 is highly expressed in endothelial cells, cardiac tissues, and the renal system, where it contributes to fluid balance, renal function, and cardiovascular homeostasis. Its role in angiogenesis makes it essential for fetal development and tissue repair. Dysregulation of RAMP2 signaling has been implicated in diseases such as preeclampsia, pulmonary hypertension, and chronic heart failure, where impaired vascular function exacerbates pathological conditions. RAMP2 also exerts protective effects during inflammatory processes by reducing endothelial damage and promoting immune cell recruitment. Therapeutic modulation of RAMP2 function has potential applications in vascular diseases, hypertension, and conditions requiring enhanced angiogenic responses, such as wound healing or ischemic injuries.
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