Receptor Activity Modifying Protein 2 (RAMP2) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Receptor Activity Modifying Protein 2 (RAMP2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx178218
tested applications
WB, IHC, IF/ICC
Description
Receptor Activity Modifying Protein 2 (RAMP2) Antibody is a Rabbit Polyclonal antibody against Receptor Activity Modifying Protein 2 (RAMP2).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Receptor Activity Modifying Protein 2 (RAMP2) Immunogen: abx654910 - Recombinant Receptor Activity Modifying Protein 2 (RAMP2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | RAMP2 |
| Background | Antibody anti-RAMP2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Receptor Activity Modifying Protein 2 (RAMP2) is another member of the RAMP family that regulates the activity of GPCRs by interacting with the calcitonin receptor-like receptor (CRLR) to form the adrenomedullin (AM) receptor. Adrenomedullin, a potent vasodilatory peptide, plays a key role in vascular biology, angiogenesis, and fluid balance. RAMP2-AM receptor signaling is crucial for maintaining endothelial integrity, promoting vascular smooth muscle relaxation, and enhancing nitric oxide production to regulate blood pressure. RAMP2 is highly expressed in endothelial cells, cardiac tissues, and the renal system, where it contributes to fluid balance, renal function, and cardiovascular homeostasis. Its role in angiogenesis makes it essential for fetal development and tissue repair. Dysregulation of RAMP2 signaling has been implicated in diseases such as preeclampsia, pulmonary hypertension, and chronic heart failure, where impaired vascular function exacerbates pathological conditions. RAMP2 also exerts protective effects during inflammatory processes by reducing endothelial damage and promoting immune cell recruitment. Therapeutic modulation of RAMP2 function has potential applications in vascular diseases, hypertension, and conditions requiring enhanced angiogenic responses, such as wound healing or ischemic injuries.
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Human Receptor Activity Modifying Protein 2 (RAMP2) Protein
Human Receptor Activity Modifying Protein 2 (RAMP2) Protein is a recombinant Human protein expressed in E. coli.
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