Mouse Receptor Activity Modifying Protein 1 (RAMP1) ELISA Kit
715€ (96 tests)
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935106861
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name
Mouse Receptor Activity Modifying Protein 1 (RAMP1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx541353
tested applications
ELISA
Description
Mouse Receptor Activity Modifying Protein 1 (RAMP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse RAMP1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Receptor Activity Modifying Protein 1 (RAMP1) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9WTJ5 |
| Alias | RAMP1,CTR |
| Background | Elisa Kits for: RAMP1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
Receptor Activity Modifying Protein 1 (RAMP1) is a member of the RAMP family that plays a crucial role in modulating the activity and function of G-protein-coupled receptors (GPCRs), particularly the calcitonin receptor-like receptor (CRLR). RAMP1 specifically partners with CRLR to form the calcitonin gene-related peptide (CGRP) receptor, which is involved in diverse physiological processes, including vasodilation, pain modulation, and neurogenic inflammation. CGRP signaling, facilitated by RAMP1, is critical for maintaining vascular homeostasis by relaxing vascular smooth muscle cells and increasing blood flow. This pathway also contributes to migraine pathophysiology, where elevated CGRP levels and RAMP1 expression have been linked to migraine attacks. RAMP1 is expressed in vascular endothelial cells, sensory neurons, and tissues like the heart, lungs, and brain, underscoring its systemic relevance. Beyond vasodilation, RAMP1-CGRP signaling protects against ischemic injuries and contributes to cardioprotection during cardiac stress. Additionally, RAMP1 modulates the activity of other receptors, such as the adrenomedullin receptor, influencing fluid homeostasis and immune regulation. Targeting RAMP1 for therapeutic intervention, particularly through antagonists, has shown promise for treating migraines, hypertension, and inflammatory disorders.
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