Receptor Activity Modifying Protein 2 (RAMP2) Antibody (FITC)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
RAMP2 Antibody (FITC) is a Rabbit Polyclonal against RAMP2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Receptor Activity Modifying Protein 2 (RAMP2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60895 |
| Gene ID | 10266 |
| Alias | RAMP2 |
| Background | Antibody anti-RAMP2 |
| Status | RUO |
Descripción
Receptor Activity Modifying Protein 2 (RAMP2) is another member of the RAMP family that regulates the activity of GPCRs by interacting with the calcitonin receptor-like receptor (CRLR) to form the adrenomedullin (AM) receptor. Adrenomedullin, a potent vasodilatory peptide, plays a key role in vascular biology, angiogenesis, and fluid balance. RAMP2-AM receptor signaling is crucial for maintaining endothelial integrity, promoting vascular smooth muscle relaxation, and enhancing nitric oxide production to regulate blood pressure. RAMP2 is highly expressed in endothelial cells, cardiac tissues, and the renal system, where it contributes to fluid balance, renal function, and cardiovascular homeostasis. Its role in angiogenesis makes it essential for fetal development and tissue repair. Dysregulation of RAMP2 signaling has been implicated in diseases such as preeclampsia, pulmonary hypertension, and chronic heart failure, where impaired vascular function exacerbates pathological conditions. RAMP2 also exerts protective effects during inflammatory processes by reducing endothelial damage and promoting immune cell recruitment. Therapeutic modulation of RAMP2 function has potential applications in vascular diseases, hypertension, and conditions requiring enhanced angiogenic responses, such as wound healing or ischemic injuries.
Related Products
anti- RAMP2 antibody
Transports the calcitonin gene-related peptide type 1 receptor(CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin(AM) together with CALCRL.
Ver Producto
Receptor Activity Modifying Protein 2 (RAMP2) Antibody
RAMP2 Antibody is a Rabbit Polyclonal antibody against RAMP2. The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
Ver Producto
Receptor Activity Modifying Protein 2 (RAMP2) Antibody
Receptor (G Protein-Coupled) Activity Modifying Protein 2 Antibody is a Rabbit Polyclonal antibody against Receptor (G Protein-Coupled) Activity Modifying Protein 2.
Ver Producto