Family main features
Diphthamide biosynthesis refers to the highly conserved post-translational modification of a specific histidine residue in eukaryotic elongation factor 2 (eEF2). This unique modification involves a multistep enzymatic process that converts histidine to diphthamide, a critical determinant for cellular translation fidelity and regulation. The diphthamide residue is the target for diphtheria toxin and certain other bacterial toxins, which ADP-ribosylate eEF2, thereby inhibiting protein synthesis and leading to cell death. The conservation of this modification across species from yeast to humans underscores its biological significance.
The proteins involved in diphthamide biosynthesis typically include a series of enzymes encoded by the DPH genes. The core enzymes include:
The DPH protein family consists of several members, each playing a role in different stages of diphthamide biosynthesis:
The diphthamide modification of eEF2 is crucial for maintaining the accuracy of protein synthesis by:
Mutations or dysregulation in DPH genes can lead to several clinical problems, such as:
Diphthamide biosynthesis is a crucial biological process involving a series of enzymatic steps to modify histidine residues in eEF2. This modification ensures high fidelity in protein translation and provides a specific target for bacterial toxins, linking it to cellular defense mechanisms. The proteins involved in this pathway are highly conserved across species, underscoring their fundamental biological importance. Dysregulation of diphthamide biosynthesis is associated with susceptibility to infections, cancer, and potentially neurological disorders, highlighting its clinical significance. Understanding this process at the molecular level provides insights into its roles in health and disease.
diphthamide biosynthesis 1 (DPH1)
DPH2L,OVCA1,DEDSSH,DPH2L1,Diphthamide biosynthesis protein 1,Diphtheria toxin resistance protein 1,Ovarian cancer-associated gene 1 protein
diphthamide biosynthesis 2 (DPH2)
DPH2L2,DEDSSH2,Diphthamide biosynthesis protein 2,Diphtheria toxin resistance protein 2
diphthamide biosynthesis 3 (DPH3)
DESR1,DPH3A,KTI11,ZCSL2,DELGIP,DELGIP1,CSL-type zinc finger-containing protein 2,DelGEF-interacting protein 1
diphthamide biosynthesis 3 pseudogene 1 (DPH3P1)
DPH3B,ZCSL1,C20orf143,CSL-type zinc finger-containing protein 1,Putative DPH3 homolog B
diphthamide biosynthesis 5 (DPH5)
AD-018,CGI-30,NEDSFF,NPD015,HSPC143,Diphthamide biosynthesis methyltransferase,Diphthine methyl ester synthase
diphthamine biosynthesis 6 (DPH6)
ATPBD4,ATP-binding domain-containing protein 4,Diphthamide synthase,Diphthine-ammonia ligase
diphthamine biosynthesis 7 (DPH7)
RRT2,WDR85,C9orf112,WD repeat-containing protein 85,Diphthamide biosynthesis protein 7,Diphthine methyltransferase
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits, Proteins and Peptides) relacionados con DPH - diphthamide biosynthesis
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 53 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | DPH1 | abx259751 | Human Diphthamide Biosynthesis Protein 1 / OVCA1 (DPH1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q9BZG8 | RUO |
Abbexa | DPH2 | abx386977 | Human Diphthamide Biosynthesis Protein 2 (DPH2) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q9BQC3 | RUO |
Abbexa | DPH3 | abx510886 | Human DPH3 homolog (DPH3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q96FX2 | RUO | ||
Abbexa | DPH3P1 | abx510888 | Human Putative DPH3 homolog B (DPH3P1) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9H4G8 | RUO | ||
Abbexa | DPH5 | abx510890 | Human Diphthine synthase (DPH5) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9H2P9 | RUO | ||
Abbexa | DPH6 | abx385964 | Human Diphthine--ammonia ligase (DPH6) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.19 ng/ml | 687.5 | 96 tests | Q7L8W6 | RUO |
Abbexa | DPH6 | abx502992 | Human Diphthine-Ammonia Ligase (DPH6) ELISA Kit | Human | Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. | 687.5 | 96 tests | RUO | ||||
Abbexa | DPH7 | abx510896 | Human Diphthamide biosynthesis protein 7 (DPH7) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9BTV6 | RUO | ||
Abbexa | DPH1 | abx510879 | Mouse Diphthamide biosynthesis protein 1 (DPH1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5NCQ5 | RUO | ||
Abbexa | DPH2 | abx510883 | Mouse Diphthamide biosynthesis protein 2 (DPH2) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9CR25 | RUO | ||
Abbexa | DPH3 | abx510887 | Mouse DPH3 homolog (DPH3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8K0W9 | RUO | ||
Abbexa | DPH5 | abx510891 | Mouse Diphthine synthase (DPH5) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9CWQ0 | RUO | ||
Abbexa | DPH6 | abx502993 | Mouse Diphthine-Ammonia Ligase (DPH6) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9CQ28 | RUO | ||
Abbexa | DPH6 | abx510894 | Mouse Diphthine--ammonia ligase (DPH6) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9CQ28 | RUO | ||
Abbexa | DPH7 | abx510897 | Mouse Diphthamide biosynthesis protein 7 (DPH7) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9CYU6 | RUO | ||
Abbexa | DPH2 | abx510884 | Rat Diphthamide Biosynthesis Protein 2 (DPH2) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q568Y2 | RUO | ||
Abbexa | DPH6 | abx502994 | Rat Diphthine-Ammonia Ligase (DPH6) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | DPH2 | FNab02516 | anti- DPH2 antibody | human | polyclonal | Rabbit | DPH2 homolog(S. cerevisiae) | IgG | Unconjugated | ELISA, WB, IHC, IP, IF | 100µg | Q9BQC3 | RUO | |
FineTest | DPH2 | FNab02517 | anti- DPH2 antibody | human | polyclonal | Rabbit | DPH2 homolog(S. cerevisiae) | IgG | Unconjugated | ELISA, WB | 100µg | Q9BQC3 | RUO | |
FineTest | DPH6 | FNab00734 | anti- ATPBD4 antibody | human | polyclonal | Rabbit | ATP binding domain 4 | IgG | Unconjugated | ELISA, WB | 100µg | Q7L8W6 | RUO | |
Abbexa | DPH1 | abx311134 | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) Antibody (Biotin) | Human | Polyclonal | Rabbit | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) | Biotin | ELISA | 162.5 | 20 µg | Q9BZG8 | RUO | |
Abbexa | DPH1 | abx301686 | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) Antibody | Human | Polyclonal | Rabbit | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | Q9BZG8 | RUO | |
Abbexa | DPH1 | abx028904 | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) Antibody | Human | Polyclonal | Rabbit | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) | Unconjugated | ELISA, WB | 250 | 80 µl | Q9BZG8 | RUO | |
Abbexa | DPH1 | abx236045 | 2-(3-Amino-3-Carboxypropyl)Histidine Synthase Subunit 1 (DPH1) Antibody | Human | Polyclonal | Rabbit | 2-(3-Amino-3-Carboxypropyl)Histidine Synthase Subunit 1 (DPH1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | Q9BZG8 | RUO | |
Abbexa | DPH1 | abx311132 | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) Antibody (HRP) | Human | Polyclonal | Rabbit | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) | HRP | ELISA | 162.5 | 20 µg | Q9BZG8 | RUO | |
Abbexa | DPH1 | abx311133 | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) Antibody (FITC) | Human | Polyclonal | Rabbit | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) | FITC | 162.5 | 20 µg | Q9BZG8 | RUO | ||
Abbexa | DPH1 | abx112167 | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) Antibody | Human | Polyclonal | Rabbit | 2-(3-Amino-3-Carboxypropyl)histidine Synthase Subunit 1 (DPH1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q9BZG8 | RUO | |
Abbexa | DPH2 | abx030152 | Diphthamide Biosynthesis Protein 2 (DPH2) Antibody | Human | Polyclonal | Rabbit | Diphthamide Biosynthesis Protein 2 (DPH2) | Unconjugated | ELISA, WB | 250 | 80 µl | Q9BQC3 | RUO | |
Abbexa | DPH2 | abx310538 | Diphthamide Biosynthesis Protein 2 (DPH2) Antibody (FITC) | Human | Polyclonal | Rabbit | Diphthamide Biosynthesis Protein 2 (DPH2) | FITC | 162.5 | 20 µg | Q9BQC3 | RUO | ||
Abbexa | DPH2 | abx310539 | Diphthamide Biosynthesis Protein 2 (DPH2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Diphthamide Biosynthesis Protein 2 (DPH2) | Biotin | ELISA | 162.5 | 20 µg | Q9BQC3 | RUO | |
Abbexa | DPH2 | abx310537 | Diphthamide Biosynthesis Protein 2 (DPH2) Antibody (HRP) | Human | Polyclonal | Rabbit | Diphthamide Biosynthesis Protein 2 (DPH2) | HRP | ELISA | 162.5 | 20 µg | Q9BQC3 | RUO | |
Abbexa | DPH2 | abx232516 | Diphthamide Biosynthesis Protein 2 (DPH2) Antibody | Human | Polyclonal | Rabbit | Diphthamide Biosynthesis Protein 2 (DPH2) | Unconjugated | ELISA, WB, IHC, IF/ICC, IP | 350 | 100 µg | Q9BQC3 | RUO | |
Abbexa | DPH2 | abx318413 | Diphthamide Biosynthesis Protein 2 (DPH2) Antibody | Human | Polyclonal | Rabbit | Diphthamide Biosynthesis Protein 2 (DPH2) | Unconjugated | ELISA, WB, IHC | 162.5 | 20 µg | Q9BQC3 | RUO | |
Abbexa | DPH2 | abx232517 | Diphthamide Biosynthesis Protein 2 (DPH2) Antibody | Human | Polyclonal | Rabbit | Diphthamide Biosynthesis Protein 2 (DPH2) | Unconjugated | ELISA, WB | 350 | 100 µg | Q9BQC3 | RUO | |
Abbexa | DPH2 | abx112168 | Diphthamide Biosynthesis Protein 2 (DPH2) Antibody | Human | Polyclonal | Rabbit | Diphthamide Biosynthesis Protein 2 (DPH2) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q9BQC3 | RUO | |
Abbexa | DPH3 | abx308895 | DPH3 Homolog (DPH3) Antibody (FITC) | Human | Polyclonal | Rabbit | DPH3 Homolog (DPH3) | FITC | 162.5 | 20 µg | Q96FX2 | RUO | ||
Abbexa | DPH3 | abx308894 | DPH3 Homolog (DPH3) Antibody (HRP) | Human | Polyclonal | Rabbit | DPH3 Homolog (DPH3) | HRP | ELISA | 162.5 | 20 µg | Q96FX2 | RUO | |
Abbexa | DPH3 | abx308893 | DPH3 Homolog (DPH3) Antibody | Human | Polyclonal | Rabbit | DPH3 Homolog (DPH3) | Unconjugated | ELISA | 162.5 | 20 µg | Q96FX2 | RUO | |
Abbexa | DPH3 | abx308896 | DPH3 Homolog (DPH3) Antibody (Biotin) | Human | Polyclonal | Rabbit | DPH3 Homolog (DPH3) | Biotin | ELISA | 162.5 | 20 µg | Q96FX2 | RUO | |
Abbexa | DPH5 | abx348789 | Diphthine methyl ester synthase (DPH5) Antibody (FITC) | Human | Polyclonal | Rabbit | Diphthine methyl ester synthase (DPH5) | FITC | 250 | 50 µl | Q9H2P9 | RUO | ||
Abbexa | DPH5 | abx348790 | Diphthine methyl ester synthase (DPH5) Antibody (Biotin) | Human | Polyclonal | Rabbit | Diphthine methyl ester synthase (DPH5) | Biotin | ELISA | 250 | 50 µl | Q9H2P9 | RUO | |
Abbexa | DPH5 | abx348788 | Diphthine methyl ester synthase (DPH5) Antibody (HRP) | Human | Polyclonal | Rabbit | Diphthine methyl ester synthase (DPH5) | HRP | ELISA | 250 | 50 µl | Q9H2P9 | RUO | |
Abbexa | DPH5 | abx348787 | Diphthine methyl ester synthase (DPH5) Antibody | Human | Polyclonal | Rabbit | Diphthine methyl ester synthase (DPH5) | Unconjugated | ELISA, IHC, IF/ICC | 250 | 50 µl | Q9H2P9 | RUO | |
Abbexa | DPH6 | abx301445 | ATP-Binding Domain-Containing Protein 4 (DPH6) Antibody | Human | Polyclonal | Rabbit | ATP-Binding Domain-Containing Protein 4 (DPH6) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q7L8W6 | RUO | |
Abbexa | DPH6 | abx145559 | ATP-Binding Domain-Containing Protein 4 (ATPBD4) Antibody | Human | Polyclonal | Rabbit | ATP-Binding Domain-Containing Protein 4 (ATPBD4) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | DPH6 | abx230734 | ATP-Binding Domain-Containing Protein 4 (ATPBD4) Antibody | Human | Polyclonal | Rabbit | ATP-Binding Domain-Containing Protein 4 (ATPBD4) | Unconjugated | ELISA, WB | 350 | 100 µg | Q7L8W6 | RUO | |
Abbexa | DPH7 | abx313822 | Dipeptidyl Peptidase 7 (DPH7) Antibody (Biotin) | Human | Polyclonal | Rabbit | Dipeptidyl Peptidase 7 (DPH7) | Biotin | ELISA | 162.5 | 20 µg | Q9BTV6 | RUO | |
Abbexa | DPH7 | abx313821 | Dipeptidyl Peptidase 7 (DPH7) Antibody (FITC) | Human | Polyclonal | Rabbit | Dipeptidyl Peptidase 7 (DPH7) | FITC | 162.5 | 20 µg | Q9BTV6 | RUO | ||
Abbexa | DPH7 | abx313820 | Dipeptidyl Peptidase 7 (DPH7) Antibody (HRP) | Human | Polyclonal | Rabbit | Dipeptidyl Peptidase 7 (DPH7) | HRP | ELISA | 162.5 | 20 µg | Q9BTV6 | RUO | |
Abbexa | DPH7 | abx313819 | Diphthine Methyltransferase (DPH7) Antibody | Human | Polyclonal | Rabbit | Diphthine Methyltransferase (DPH7) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q9BTV6 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | DPH2 | abx680238 | Human Diphthamide Biosynthesis Protein 2 (DPH2) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 1 µg | RUO | |
Abbexa | DPH3P1 | abx261295 | Diphthamide Biosynthesis 3 Pseudogene 1 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | Q9H4G8 | RUO | ||
FineTest | DPH3P1 | P6668 | Recombinant Human DPH3P1 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q9H4G8 | RUO |
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